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Diabetes und Demenz

Diabetes and dementia

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Zusammenfassung

Diabetes mellitus ist ein bekannter Risikofaktor für kognitive Störungen und Demenzerkrankungen. Bei der Entwicklung kognitiver Störungen spielen neben der chronischen Hyperglykämie weitere Faktoren wie genetische Prädisposition, arterielle Hypertonie, Hyperlipoproteinämie, mikro- und makrovaskuläre Erkrankungen sowie die Depression eine wichtige Rolle. In der vorliegenden Übersichtsarbeit werden sowohl die pathophysiologische Zusammenhänge zwischen den Erkrankungen Diabetes und Demenz als auch die Besonderheiten der Diabetestherapie bei Demenzerkrankten differenziert dargestellt.

Abstract

Diabetes mellitus is a known risk factor for cognitive dysfunction and dementia. Chronic hyperglycemia, genetic predisposition, arterial hypertension, hyperlipoproteinemia, micro- and macrovascular diseases, and depression play a major role in the development of cognitive dysfunction. Both pathophysiology of diabetes and dementia and the specifics of diabetes therapy in patients with dementia are presented in this review.

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Interessenkonflikt

Die korrespondierende Autorin gibt an, dass kein Interessenkonflikt besteht. A.B. und P.B. sind Stipendiaten des Forschungskollegs Geriatrie der Robert-Bosch-Stiftung.

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Authors and Affiliations

  1. Medizinische Klinik 2, Friedrich-Alexander-Universität Erlangen-Nürnberg, Ulmenweg 18, 91054, Erlangen, Deutschland

    A. Bahrmann & W.G. Daniel

  2. Medizinische Klinik 2 , Klinikum Nürnberg, Nürnberg, Deutschland

    P. Bahrmann & C.C. Sieber

  3. Institut für Biomedizin des Alterns, Lehrstuhl für Innere Medizin – Geriatrie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Nürnberg, Deutschland

    P. Bahrmann & C.C. Sieber

  4. Psychologisches Institut, Universität Mainz, Mainz, Deutschland

    T. Kubiak

  5. Klinik für Geriatrie, Marienkrankenhaus Hamburg, Hamburg, Deutschland

    D. Kopf

  6. AGAPLESION Bethanien-Krankenhaus, Geriatrisches Zentrum am Klinikum der Ruprecht-Karls-Universität Heidelberg, Heidelberg, Deutschland

    P. Oster

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  1. A. Bahrmann
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  2. P. Bahrmann
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  3. T. Kubiak
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  4. D. Kopf
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  5. P. Oster
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  6. C.C. Sieber
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  7. W.G. Daniel
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Correspondence to A. Bahrmann.

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Bahrmann, A., Bahrmann, P., Kubiak, T. et al. Diabetes und Demenz. Z Gerontol Geriat 45, 17–22 (2012). https://doi.org/10.1007/s00391-011-0269-z

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  • DOI: https://doi.org/10.1007/s00391-011-0269-z

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