Skip to main content

Advertisement

SpringerLink
Log in

Enhanced contact endoscopy for the assessment of the neoangiogenetic changes in precancerous and cancerous lesions of the oral cavity and oropharynx

  • Head and Neck
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Dysplasia and squamous cell carcinoma of the upper aerodigestive tract show significant neoangiogenesis appearing as subepithelial and epithelial microvascular irregularities that can be detected by Image-Enhanced Endoscopy such as Narrow Band Imaging and Storz Professional Image Enhancement System. In the present study, the most advanced endoscopic enhancement systems were coupled with Contact Endoscopy (Enhanced Contact Endoscopy). This original method improved the identification and the understanding of the neoangiogenetic changes of the chorion in 42 patients with leukoplakia, erythroplakia, and leuko-erythroplakia of the oral cavity and oropharynx. The physiologic and pathologic mucosa was described in five obvious vascular patterns observed at Enhanced Contact Endoscopy ranging from normal to squamous cell carcinoma, passing through inflammation, hyperplasia, and dysplasia. Each vascular pattern was then compared to histology, showing that the microvascular architectural changes seen with Enhanced Contact Endoscopy are almost constant. Sensitivity, specificity, positive predictive value, and negative predictive value in the differentiation between healthy mucosa and inflammation versus pathologic hyperplasia, dysplasia, and carcinoma were, respectively, 96.6, 93.3, 98.2, 87.5, and 95.9 %. Sensitivity and specificity were 100 % in differentiation between non-malignant lesions versus squamous cell carcinoma. Our preliminary experience shows that accuracy of Image-Enhanced Endoscopy in the diagnosis of precancerous lesions and squamous cell carcinoma of the oral cavity and oropharynx can be increased if associated to Contact Endoscopy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Johnstone S, Logan RM (2006) The role of vascular endothelial growth factor (VEGF) in oral dysplasia and oral squamous cell carcinoma. Oral Oncol 42:337–342

    Article  CAS  PubMed  Google Scholar 

  2. Tao X, Huang Y, Li R, Qing R, Ma L, Rhodus NL (2007) Assessment of local angiogenesis and vascular endothelial growth factor in the patients with atrophic-erosive and reticular oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:661–669

    Article  PubMed  Google Scholar 

  3. Sharma S, Sharma MC, Sarkar C (2005) Morphology of angiogenesis in human cancer: a conceptual overview, histoprognostic perspective and significance of neoangiogenesis. Histopathology 46:481–489

    Article  CAS  PubMed  Google Scholar 

  4. Yang SW, Lee YS, Chang LC, Hsieh TY, Chen TA (2013) Implications of morphologic patterns of intraepithelial microvasculature observed by narrow-band imaging system in cases of oral squamous cell carcinoma. Oral Oncol 49:86–92

    Article  PubMed  Google Scholar 

  5. Hamou J, Salat-Baroux J, Coupez F, De Brux J (1984) Microhysteroscopy: a new approach to the diagnosis of cervical intraepithelial neoplasia. Obstet Gynecol 63:567–574

    CAS  PubMed  Google Scholar 

  6. Andrea M, Dias O, Macor C, Santos A, Varandas J (1997) Contact endoscopy of the nasal mucosa. Acta Otolaryngol 117:307–311

    Article  CAS  PubMed  Google Scholar 

  7. Andrea M, Dias O, Santos A (1995) Contact endoscopy of the vocal cord: normal and pathological patterns. Acta Otolaryngol 115:314–316

    Article  CAS  PubMed  Google Scholar 

  8. Pak MW, To KF, Leung SF, Van Hasselt CA (2002) In vivo diagnosis of persistent and recurrent nasopharyngeal carcinoma by contact endoscopy. Laryngoscope 112:1459–1466

    Article  PubMed  Google Scholar 

  9. Pelucchi S, Bianchini C, Travagli M, Pastore A (2007) Contact endoscopy of the oral mucosa: preliminary results. Acta Otorhinolaryngol Ital 27:59–61

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Warnecke A, Averbeck T, Leinung M, Soudah B, Wenzel GI, Kreipe HH, Lenarz T, Stöver T (2010) Contact endoscopy for the evaluation of the pharyngeal and laryngeal mucosa. Laryngoscope 120:253–258

    PubMed  Google Scholar 

  11. Hamamoto Y, Endo T, Nosho K, Arimura Y, Sato M, Imai K (2004) Usefulness of narrow band imaging endoscopy for diagnosis of Barrett’s esophagus. J Gastroenterol 39:14–20

    Article  PubMed  Google Scholar 

  12. Kara MA, Ennahachi M, Fockens P, ten Kate FJ, Bergman JJ (2006) Detection and classification of the mucosal and vascular pattern (mucosal morphology) in Barrett’s esophagus by using narrow band imaging. Endoscopy 38:627–631

    Article  CAS  PubMed  Google Scholar 

  13. Coriat R, Chryssostalis A, Zeitoun JD, Deyra J, Gaudric M, Prat F, Chaussade S (2008) Computed virtual chromoendoscopy system (FICE): a new tool for upper endoscopy? Gastroenterol Clin Biol 32:363–369

    Article  CAS  PubMed  Google Scholar 

  14. Pohl J, May A, Rabenstein T, Pech O, Ell C (2007) Computed virtual chromoendoscopy: a new tool for enhancing tissue surface structures. Endoscopy 39:80–83

    Article  CAS  PubMed  Google Scholar 

  15. Galloro G (2012) High technology imaging in digestive endoscopy. World J Gastrointest Endosc 4:22–27

    Article  PubMed  PubMed Central  Google Scholar 

  16. Piazza C, Dessouky O, Peretti G, Cocco D, De Benedetto L, Nicolai P (2008) Narrow-band imaging: a new tool for evaluation of head and neck squamous cell carcinomas. Review of the literature. Acta Otorhinolaryngol Ital 28:49–54

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Watanabe A, Taniguchi M, Tsujie H, Hosokawa M, Fujita M, Sasaki S (2009) The value of narrow band imaging for early detection of laryngeal cancer. Eur Arch Otorhinolaryngol 266:1017–1023

    Article  PubMed  Google Scholar 

  18. Muto M, Minashi K, Yano T, Saito Y, Oda I, Nonaka S, Omori T, Sugiura H, Goda K, Kaise M, Inoue H, Ishikawa H, Ochiai A, Shimoda T, Watanabe H, Tajiri H, Saito D (2010) Early detection of superficial squamous cell carcinoma in the head and neck region and esophagus by narrow band imaging: a multicenter randomized controlled trial. J Clin Oncol 28:1566–1572

    Article  PubMed  PubMed Central  Google Scholar 

  19. Tan NC, Herd MK, Brennan PA, Puxeddu R (2012) The role of narrow band imaging in early detection of head and neck cancer. Br J Oral Maxillofac Surg 50:132–136

    Article  PubMed  Google Scholar 

  20. Puxeddu R, Sionis S, Gerosa C, Carta F (2015) Enhanced contact endoscopy for the detection of neoangiogenesis in tumors of larynx and hypopharynx. Laryngoscope. doi:10.1002/lary.25124

    PubMed  Google Scholar 

  21. Green B, Cobb AR, Brennan PA, Hopper C (2014) Optical diagnostic techniques for use in lesions of the head and neck: review of the latest developments. Br J Oral Maxillofac Surg 52:675–680

    Article  PubMed  Google Scholar 

  22. Piazza C, Cocco D, Del Bon F, Mangili S, Nicolai P, Peretti G (2011) Narrow band imaging and high definition television in the endoscopic evaluation of upper aero-digestive tract cancer. Acta Otorhinolaryngol Ital 31:70–75

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Yang SW, Lee YS, Chang LC, Hwang CC, Chen TA (2012) Diagnostic significance of narrow-band imaging for detecting high-grade dysplasia, carcinoma in situ, and carcinoma in oral leukoplakia. Laryngoscope 122:2754–2761

    Article  PubMed  Google Scholar 

  24. Ni XG, He S, Xu ZG, Gao L, Lu N, Yuan Z, Lai SQ, Zhang YM, Yi JL, Wang XL, Zhang L, Li XY, Wang GQ (2011) Endoscopic diagnosis of laryngeal cancer and precancerous lesions by narrow band imaging. J Laryngol Otol 125:288–296

    Article  PubMed  Google Scholar 

  25. Takano JH, Yakushiji T, Kamiyama I, Nomura T, Katakura A, Takano N, Shibahara T (2010) Detecting early oral cancer: narrowband imaging system observation of the oral mucosa microvasculature. Int J Oral Maxillofac Surg 39:208–213

    Article  CAS  PubMed  Google Scholar 

  26. Slaughter DP, SouthwickHW SmejkalW (1953) Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 6:963–968

    Article  CAS  PubMed  Google Scholar 

  27. Jaiswal G, Jaiswal S, Kumar R, Sharma A (2013) Field cancerization: concept and clinical implications in head and neck squamous cell carcinoma. J Exp Ther Oncol 10:209–214

    PubMed  Google Scholar 

  28. Mishra AK, Nilakantan A, Sahai K, Datta R, Malik A (2014) Contact Endoscopy of mucosal lesions of oral cavity—preliminary experience. Med J Armed Forces India 70:257–263

    Article  PubMed  PubMed Central  Google Scholar 

  29. Nakayoshi T, Tajiri H, Matsuda K, Kaise M, Ikegami M, Sasaki H (2004) Magnifying endoscopy combined with narrow band imaging system for early gastric cancer: correlation of vascular pattern with histopathology (including video). Endoscopy 36:1080–1084

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

Gratefully acknowledges Sardinia Regional Government for the financial support (P.O.R. Sardegna F.S.E. Operational Programme of the Autonomous Region of Sardinia, European Social Fund 2007–2013—Axis IV Human Resources, Objective l.3, Line of Activity l.3.1 “Avviso di chiamata per il finanziamento di Assegni di Ricerca.”

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology, School of Medicine, Azienda Ospedaliero-Universitaria, P.O. S Giovanni di Dio, University of Cagliari, Via Ospedale 54, 09124, Cagliari, Italy

    Filippo Carta, Sara Sionis & Roberto Puxeddu

  2. Department of General Surgery, Maricopa Integrated Health System, 2601 E. Roosvelt Street, Phoenix, AZ, 85008, USA

    Daniela Cocco

  3. Section of Pathology, Department of Surgery, School of Medicine, Azienda Ospedaliero-Universitaria, P.O. S Giovanni di Dio, University of Cagliari, Via Ospedale 54, 09124, Cagliari, Italy

    Clara Gerosa

  4. M. Aresu Department of Medical Science - Section of Dermatology, School of Medicine, Azienda Ospedaliero-Universitaria, P.O. S Giovanni di Dio, University of Cagliari, Via Ospedale 54, 09124, Cagliari, Italy

    Caterina Ferreli

Authors
  1. Filippo Carta
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sara Sionis
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Daniela Cocco
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Clara Gerosa
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Caterina Ferreli
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Roberto Puxeddu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Filippo Carta.

Ethics declarations

Authors have no financial conflict of interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Carta, F., Sionis, S., Cocco, D. et al. Enhanced contact endoscopy for the assessment of the neoangiogenetic changes in precancerous and cancerous lesions of the oral cavity and oropharynx. Eur Arch Otorhinolaryngol 273, 1895–1903 (2016). https://doi.org/10.1007/s00405-015-3698-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-015-3698-2

Keywords

Search

Navigation