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High concurrent presence of disability in multiple sclerosis

Associations with perceived health

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Abstract

Objectives

(1) To explore functioning and concurrent presence of disabilities — concerning cognition, manual dexterity, walking, energy, mood, activities of daily living (ADL), and social/lifestyle activities — in persons with multiple sclerosis (PwMS) cared for at an outpatient MS clinic. 2) To describe the PwMS’ perceived physical and psychological impact and associations with the same disabilities.

Material/methods

A descriptive cross-sectional study was carried out in 219 PwMS at the MS Centre, Karolinska University Hospital. Logistic regression employing proportional odds models was used to identify the associations of the disabilities with the perceived physical and psychological impact.

Results

In this sample the distribution with regard to disease severity as per Expanded Disability Status Scale was; mild 59.5%, moderate 17% and severe 23.5%. Despite the high proportion with mild disease severity disability regarding cognition was found in 49%, manual dexterity 76%, walking 43%, energy 67%, mood 29%, ADL 44% and social/lifestyle activities in 48%. Two or more disabilities were found in 80%, 24 % had six or seven disabilities. Disability regarding energy, mood, walking, manual dexterity and ADL was significantly associated with increase in the perceived physical impact, whereas disability in energy and mood was significantly associated with increase in the perceived psychological impact.

Conclusions

The presence of several concurrent disabilities, some significantly associated with high perceived physical and psychological impact, in the majority of PwMS in outpatient clinics highlights the importance to identify disabilities, in particular fatigue and depressed mood, in order to supply health care interventions aiming to improve the life situation of PwMS.

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Authors and Affiliations

  1. Division of Neurology, Dept. of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital Huddinge, SE-141 86, Stockholm, Sweden

    Sverker Johansson, Charlotte Ytterberg, Jan Hillert, Lotta Widén Holmqvist & Lena von Koch

  2. Dept. of Physical Therapy, Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden

    Ingrid M. Claesson & Jenny Lindberg

  3. Division of Neurology, Dept. of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital Solna, 171 77, Stockholm, Sweden

    Magnus Andersson

  4. Division of Physiotherapy 23100, Dept. of Neurobiology, Care Sciences and Society, Karolinska Institutet, 141 83, Stockholm, Sweden

    Sverker Johansson, Charlotte Ytterberg & Lotta Widén Holmqvist

Authors
  1. Sverker Johansson
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  2. Charlotte Ytterberg
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  3. Ingrid M. Claesson
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  4. Jenny Lindberg
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  5. Jan Hillert
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  6. Magnus Andersson
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  7. Lotta Widén Holmqvist
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  8. Lena von Koch
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Corresponding author

Correspondence to Sverker Johansson.

Additional information

Sverker Johansson and Charlotte Ytterberg contributed equally to this study.

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Johansson, S., Ytterberg, C., Claesson, I.M. et al. High concurrent presence of disability in multiple sclerosis. J Neurol 254, 767–773 (2007). https://doi.org/10.1007/s00415-006-0431-5

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  • DOI: https://doi.org/10.1007/s00415-006-0431-5

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