Abstract
Fatigue is one of the most common symptoms in patients with Parkinson’s disease (PD), and its impact on the quality of life is substantial. However, its cause and treatment are not established. Fatigue in PD has two components, peripheral and central, which may be related to each other, but are more likely independent. Fatigue is partially associated with depression or sleep disorders, but patients with fatigue are not always depressed and do not necessarily have sleep problems. Anti-PD drugs may exacerbate or reduce fatigue. The impact of fatigue in PD is often underestimated by health-care providers.
Similar content being viewed by others
References
Abe K, Takanashi M, Yanagihara T (2000) Fatigue in patients with Parkinson’s disease. Behav Neurol 12:103–106
Abe K, Takanashi M, Yanagihara T et al. (2001–2002) Pergolide mesilate may improve fatigue in patients with Parkinson’s disease. Behav Neurol 13:117–121
Abudi S, Bar-Tal Y, Ziv L et al. (1997) Parkinson’s disease symptoms—patient’s perception. J Adv Nurs 25:54–59
Boer AG, Wijker W, Speelman JD et al. (1996) Quality of life in patients with Parkinson’s disease: development of a questionnaire. J Neurol Neurosurg Psychiatry 61:70–74
Brown RG, Dittner A, Findley L et al. (2005) The Parkinson fatigue scale. Parkinsonism Relat Disord 11:49–55
Burn DJ (2002) Beyond the iron mask: towards better recognition and treatment of depression associated with Parkinson’s disease. Mov Disord 17:445–454
Cathebras PJ, Robbins JM, Kirmayer LJ et al. (1992) Fatigue in primary care: prevalence, psychiatric comorbidity, illness behavior, and outcome. J Gen Int Med 7:276–286
Chalder T, Berelowitz G, Pawlikowska T et al. (1993) Development of a fatigue scale. J Psychosom Res 37:147–153
Chaudhuri A, Behan PO (2000) Fatigue and basal ganglia. J Neurol Sci 179:34–42
David A, Pelosi A, McDonald E et al. (1990) Tired, weak, or in need of rest: fatigue among general practice attenders. Br Med J 301:1199–1202
Davis JM (1995) Central and peripheral factors in fatigue. J Sports Sci 13:S49–S53
Davis JM, Bailey SP (1997) Possible mechanisms of central nervous system fatigue during exercise. Med Sci Sports Exerc 29:45–47
Dooneief G, Mirabello E, Bell K, et al. 81992) An estimate of the incidence of depression in idiopathic Parkinson’s disease. Arch Neurol 49:305–307
Ford H, Trigwell P, Johnson M (1998) The nature of fatigue in multiple sclerosis. J Psychosom Res 45:33–38
Freal JE, Kraft GH, Coryell JK (1984) Symptomatic fatigue in multiple sclerosis. Arch Phys Med Rehabil 65:135–138
Friedman J, Friedman H (1993) Fatigue in Parkinson’s disease. Neurology 43:2016–2108
Friedman JH, Friedman H (2001) Fatigue in Parkinson’s disease: a nine-year follow-up. Mov Disord 6:1120–1122
Fulcher KY, White PD (1997) Randomized controlled trial of graded exercise in patients with the chronic fatigue syndrome. Br Med J 314:1647–1652
Funkiewiez A, Ardouin C, Krack P et al. (2003) Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson’s disease. Mov Disord 18:524–530
Garber CE, Friedman JH (2003) Effects of fatigue on physical activity and function in patients with Parkinson’s disease. Neurology 60:1119–1124
Gillson G, Richard TL, Smith RB et al. (2002) A double-blind pilot study of the effect of Prokarin on fatigue in multiple sclerosis. Mult Scler 8:30–35
Herlofson K, Larsen JP (2003) The influence of fatigue on health-related quality of life in patients with Parkinson’s disease. Acta Neurol Scand 107:1–6
Hilten JJ, Weggeman M, van der Velde EA et al. (1993) Sleep, excessive daytime sleepiness and fatigue in Parkinson’s disease. J Neural Transm (P-D Sect) 5:235–244
Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression and mortality. Neurology 17:427–442
Hwang WJ, Lin TS (2001) Evaluation of fatigue in Parkinson’s disease patients with stimulated single fiber electromyography. Acta Neurol Scand 104:271–274
Karlsen K, Larsen JP, Tandberg E et al. (1999) Fatigue in patients with Parkinson’s disease. Mov Disord 14:237–241
Kirk J, Douglass R, Nelson E et al. (1990) Chief complaint of fatigue: a prospective study. J Fam Practice 30:33–39
Kroenke K, Wood DR, Mangelsdorff AD et al. (1988) Chronic fatigue in primary care: prevalence, patient characteristics and outcome. JAMA 260:929–934
Krupp LB, LaRocca NG, Muir-Nash J et al. (1989) The fatigue severity scale. application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 46:1121–1123
Krupp LB, Pollina DA (1996) Mechanisms and management of fatigue in progressive neurological disorders. Curr Opin Neurol 9:456–460
Levi S, Cox M, Lugon M et al. (1990) Increased energy expenditure in Parkinson’s disease. Br Med J 301:1256–1257
Loge JH, Ekeberg O, Kaasa S (1998) Fatigue in the general Norwegian population: normative data and associations. J Psychosom Res 45:53–65
Lou JS, Benice T, Kearns G et al. (2003) Levodopa normalizes exercise related cortico-motoneuron excitability abnormalities in Parkinson’s disease. Clin Neurophysiol 114:930–937
Lou JS, Kearns G, Oken B et al. (2001) Exacerbated physical fatigue and mental fatigue in Parkinson’s disease. Mov Disord 16:190–196
Marek T, Noworol G, Karwowski W (1998) Mental fatigue at work and pain perception. Work Stress 2:133–137
Markus HS, Cox M, Tomkins AM (1992) Raised resting energy expenditure in Parkinson’s disease and its relationship to muscle rigidity. Clin Sci 83:199–204
Merkies IS, Schmitz PI, Samijn JP et al. (1999) Fatigue in immune-mediated polyneuropathies. Europian Inflammatory Neuropathy Cause and Treatment (INCAT) Group. Neurology 53:1648–1654
Mock V, Atkinson A, Barsevick A et al. (2000) NCCN practice guidelines for cancer-related fatigue. Oncology 14:151–161
Mostert S, Kesselring J (2002) Effects of a short-term exercise training program on aerobic fitness, fatigue, health perception and activity level of subjects with multiple sclerosis. Mult Scler 8:161–168
Peto V, Jenkinson C, Fitzpatrick R et al. (1995) The development and validation of a short measure of functioning and well being for individuals with Parkinson’s disease. Qual Life Res 4:241–248
Pogarell O, Gasser T, van Hilen JJ et al. (2002) Pramipexole in patients with Parkinson’s disease and marked drug resistant tremor: a randomized, double blind, placebo controlled multicentre study. J Neurol Neurosurg Psychiatry 72:713–720
Portenoy RK, Itri LM (1999) Cancerrelated fatigue: guidelines for evaluation and management. The Oncologist 4:1–10
Robb-Nicholson LC, Daltroy L, Eaton H et al. (1989) Effect of aerobic conditioning in lupus fatigue: a pilot study. Br J Rheumatol 28:500–505
Roelcke U, Kappos L, Lechner-Scott J et al. (1997) Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: a 18F-fluorodeoxyglucose positron emission tomography study. Neurology 48:1566–1571
Rossini PM, Pasqualetti P, Pozzilli C et al. (2001) Fatigue in progressive multiple sclerosis: results of a randomized, double-blind, placebo-controlled, crossover trial of oral 4-aminopyridine. Multi Scler 7:354–358
Schenkman M, Wei Zhu C, Cutson TM et al. (2001) Longitudinal evaluation of economic and physical impact of Parkinson’s disease. Parkinsonism Relat Disord 8:41–50
Schrag A, Jahanshahi M, Quinn N (2000) What contributes to quality of life in patients with Parkinson’s disease? J Neurol Neurosurg Psychiatry 69:308–312
Schrag A, Jahanshahi M, Quinn NP (2001) What contributes to depression in Parkinson’s disease? Psychol Med 31:65–73
Schwab RS, England AC, Peterson C (1959) Akinesia in Parkinson’s disease. Neurology 9:65–72
Schwartz A (1998) The Schwartz cancer fatigue scale: testing reliability and validity. Oncol Nurs Forum 25:711–717
Schwartz JE, Jandorf L, Krupp LB (1993) The measurement of fatigue: a new instrument. J Psychosom Res 37:753–762
Shulman LM, Taback RL, Bean J et al. (2001) Comorbidity of the nonmotor symptoms of Parkinson’s disease. Mov Disord 16:507–510
Smets EM, Garssen B, Bonke B et al. (1995) The Multidimensional Fatigue Inventry (MFI) psychosomatic qualities of an instrument to assess fatigue. J Psychosom Res 39:315–325
Swain MG (2000) Fatigue in chronic disease. Clin Sci 99:1–8
Tandberg E, Larsen JP, Aarsland D et al. (1996) The occurrence of depression in Parkinson’s disease. A community-based study. Arch Neurol 53:175–179
Taus C, Giuliani G, Pucci E et al. (2003) Amantadine for fatigue in multiple sclerosis. Cochrane Database Syst Rev 2:CD002818
Tavio M, Milan I, Tirelli U (2002) Cancer-related fatigue (review). Int J Oncol 21:1093–1099
Tolson D, Fleming V, Schartau E (2002) Coping with menstruation: understanding the needs of woman with Parkinson’s disease. J Adv Nurs 40:513–521
Vercoulen JH, Swanink CM, Galama JM et al. (1998) The persistence of fatigue in chronic fatigue syndrome and multiple sclerosis: development of a model. J Psychosom Res 45:507–517
Wang B, Gladman DD, Urowitz MB (1998) Fatigue in lupus is not correlated with disease activity. J Rheumatol 25:892–895
Weinshenker BG, Penman M, Bass B et al. (1992) A double-blind, randomized, crossover trial of pemoline in fatigue associated with multiple sclerosis. Neurology 42:1468–1471
Ziv I, Avraham M, Michaelov Y et al. (1998) Enhanced fatigue during motor performance in patients with Parkinson’s disease. Neurology 51:1583–1586
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Yoshii, F., Takahashi, H., Kumazawa, R. et al. Parkinson’s disease and fatigue. J Neurol 253 (Suppl 7), vii48–vii53 (2006). https://doi.org/10.1007/s00415-006-7011-6
Issue Date:
DOI: https://doi.org/10.1007/s00415-006-7011-6