Abstract
Purpose
The purpose of this study is to determine the influence of post-surgical corneal edema on the reliability and reproducibility of central corneal thickness (CCT) measurements by a Scheimpflug camera (Pentacam), ultrasound pachymetry (USP), and anterior-segment spectral-domain optical coherence tomography (AS-OCT).
Methods
Thirty-two patients planned for cataract surgery (n = 16) or vitrectomy (n = 6) were included in a prospective study. The non-surgery eye was used as control. Two investigators acquired two measurements each, with the Pentacam (Oculus, Germany) and the AS-OCT (Heidelberg Engineering, Germany) in a randomized order, followed by USP (Tomey SP-100, Germany). CCT was evaluated using the apex value for Pentacam, the corneal apex cut in AS–OCT and averaging eight single measurements for USP. Coefficients of variation (COV) and intra-class correlation coefficients (ICC) were determined.
Results
Post-surgery corneas showed a thickness of (investigators 1 and 2): Pentacam (615.9 ± 58.02 μm and 615.1 ± 60.17 μm), USP (601.4 ± 63.77 μm and 614.5 ± 70.91 μm), AS-OCT (608.8 ± 65.67 μm and 606.9 ± 64.41 μm) ,with no significant difference (ANOVA p > 0.99). The COVs (investigators 1 and 2) for control eyes were: Pentacam (0.78 ± 0.52 and 0.70 ± 0.76), USP (0.66 ± 0.29 and 0.98 ± 0.44), AS-OCT (0.59 ± 0.61 and 0.59 ± 0.40). The COVs (investigators 1 and 2) for post-surgical eyes were: Pentacam (0.98 ± 1.25 and 0.97 ± 0.73), USP (0.73 ± 0.64 and 1.35 ± 0.85), AS-OCT (1.34 ± 1.57 and 1.19 ± 1.18).The ICC was determined in post-surgery corneas (ICC > 0.96) and control corneas (ICC > 0.95).
Conclusion
USP measurements have the highest user dependence. Post-surgical corneal edema leads to higher intraobserver variability. All methods reached a high level of agreement in CCT determination in edematous as well as healthy corneas.
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References
Gordon MO, Beiser JA, Brandt JD, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Kass MA (2002) The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol 120(6):714–720, discussion 829–730
Huang J, Ding X, Savini G, Pan C, Feng Y, Cheng D, Hua Y, Hu X, Wang Q (2013) A Comparison between Scheimpflug imaging and optical coherence tomography in measuring corneal thickness. Ophthalmology 120(10):1951–1958. doi:10.1016/j.ophtha.2013.02.022
Jorge J, Rosado J, Diaz-Rey J, Gonzalez-Meijome J (2013) Central corneal thickness and anterior chamber depth measurement by Sirius((R)) Scheimpflug tomography and ultrasound. Clin Ophthalmol 7:417–422. doi:10.2147/OPTH.S35121
Martin R, de Juan V, Rodriguez G, Cuadrado R, Fernandez I (2007) Measurement of corneal swelling variations without removal of the contact lens during extended wear. Invest Ophthalmol Vis Sci 48(7):3043–3050. doi:10.1167/iovs.06-1372
Martin R, de Juan V, Rodriguez G, Fonseca S, Martin S (2008) Contact lens-induced corneal peripheral swelling differences with extended wear. Cornea 27(9):976–979. doi:10.1097/ICO.0b013e318172fc2c
Price FW Jr, Koller DL, Price MO (1999) Central corneal pachymetry in patients undergoing laser in situ keratomileusis. Ophthalmology 106(11):2216–2220. doi:10.1016/S0161-6420(99)90508-0
Randleman JB, Woodward M, Lynn MJ, Stulting RD (2008) Risk assessment for ectasia after corneal refractive surgery. Ophthalmology 115(1):37–50. doi:10.1016/j.ophtha.2007.03.073
Kwon RO, Price MO, Price FW Jr, Ambrosio R Jr, Belin MW (2010) Pentacam characterization of corneas with Fuchs dystrophy treated with Descemet membrane endothelial keratoplasty. J Refract Surg 26(12):972–979. doi:10.3928/1081597×-20100212-08
Miglior S, Albe E, Guareschi M, Mandelli G, Gomarasca S, Orzalesi N (2004) Intraobserver and interobserver reproducibility in the evaluation of ultrasonic pachymetry measurements of central corneal thickness. Br J Ophthalmol 88(2):174–177
Nam SM, Im CY, Lee HK, Kim EK, Kim TI, Seo KY (2010) Accuracy of RTVue optical coherence tomography, Pentacam, and ultrasonic pachymetry for the measurement of central corneal thickness. Ophthalmology 117(11):2096–2103. doi:10.1016/j.ophtha.2010.03.002
de Sanctis U, Missolungi A, Mutani B, Richiardi L, Grignolo FM (2007) Reproducibility and repeatability of central corneal thickness measurement in keratoconus using the rotating Scheimpflug camera and ultrasound pachymetry. Am J Ophthalmol 144(5):712–718. doi:10.1016/j.ajo.2007.07.021
Huang J, Pesudovs K, Yu A, Wright T, Wen D, Li M, Yu Y, Wang Q (2011) A comprehensive comparison of central corneal thickness measurement. Optom Vis Sci 88(8):940–949. doi:10.1097/OPX.0b013e31821ffe2c
Do JR, Oh JH, Chuck RS, Park CY (2015) Transient corneal edema is a predictive factor for pseudophakic cystoid macular edema after uncomplicated cataract surgery. Korean J Ophthalmol 29(1):14–22. doi:10.3341/kjo.2015.29.1.14
Hiraoka M, Amano S, Oshika T, Kato S, Hori S (2001) Factors contributing to corneal complications after vitrectomy in diabetic patients. Jpn J Ophthalmol 45(5):492–495
du Toit R, Vega JA, Fonn D, Simpson T (2003) Diurnal variation of corneal sensitivity and thickness. Cornea 22(3):205–209
Zadnik K, Mutti DO, Adams AJ (1992) The repeatability of measurement of the ocular components. Invest Ophthalmol Vis Sci 33(7):2325–2333
Al-Farhan HM, Al-Otaibi WM (2012) Comparison of central corneal thickness measurements using ultrasound pachymetry, ultrasound biomicroscopy, and the Artemis-2 VHF scanner in normal eyes. Clin Ophthalmol 6:1037–1043. doi:10.2147/OPTH.S32955
Li EY, Mohamed S, Leung CK, Rao SK, Cheng AC, Cheung CY, Lam DS (2007) Agreement among 3 methods to measure corneal thickness: ultrasound pachymetry, Orbscan II, and Visante anterior segment optical coherence tomography. Ophthalmology 114(10):1842–1847. doi:10.1016/j.ophtha.2007.02.017
Chen S, Huang J, Wen D, Chen W, Huang D, Wang Q (2012) Measurement of central corneal thickness by high-resolution Scheimpflug imaging, Fourier-domain optical coherence tomography and ultrasound pachymetry. Acta Ophthalmol 90(5):449–455. doi:10.1111/j.1755-3768.2010.01947
Savini G, Barboni P, Carbonelli M, Hoffer KJ (2011) Repeatability of automatic measurements by a new Scheimpflug camera combined with Placido topography. J Cataract Refract Surg 37(10):1809–1816. doi:10.1016/j.jcrs.2011.04.033
Piotrowiak I, Soldanska B, Burduk M, Kaluzny BJ, Kaluzny J (2012) Measuring corneal thickness with SOCT, the Scheimpflug system, and ultrasound pachymetry. ISRN Ophthalmol 2012:869319. doi:10.5402/2012/869319
Wu W, Wang Y, Xu L (2014) Meta-analysis of Pentacam vs. ultrasound pachymetry in central corneal thickness measurement in normal, post-LASIK or PRK, and keratoconic or keratoconus-suspect eyes. Graefes Arch Clin Exp Ophthalmol 252(1):91–99. doi:10.1007/s00417-013-2502-5
Pierro L, Conforto E, Resti AG, Lattanzio R (1998) High-frequency ultrasound biomicroscopy versus ultrasound and optical pachymetry for the measurement of corneal thickness. Ophthalmologica 212(1):1–3
Marsich MW, Bullimore MA (2000) The repeatability of corneal thickness measures. Cornea 19(6):792–795
Mertz GW (1980) Overnight swelling of the living human cornea. J Am Optom Assoc 51(3):211–214
Kotecha A, Crabb DP, Spratt A, Garway-Heath DF (2009) The relationship between diurnal variations in intraocular pressure measurements and central corneal thickness and corneal hysteresis. Invest Ophthalmol Vis Sci 50(9):4229–4236. doi:10.1167/iovs.08-2955
Wheeler NC, Morantes CM, Kristensen RM, Pettit TH, Lee DA (1992) Reliability coefficients of three corneal pachymeters. Am J Ophthalmol 113(6):645–651
Iester M, Telani S, Frezzotti P, Manni G, Uva M, Figus M, Perdicchi A (2012) Differences in central corneal thickness between the paired eyes and the severity of the glaucomatous damage. Eye (Lond) 26(11):1424–1430. doi:10.1038/eye.2012.179
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Kuerten, D., Plange, N., Koch, E.C. et al. Central corneal thickness determination in corneal edema using ultrasound pachymetry, a Scheimpflug camera, and anterior segment OCT. Graefes Arch Clin Exp Ophthalmol 253, 1105–1109 (2015). https://doi.org/10.1007/s00417-015-2998-y
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DOI: https://doi.org/10.1007/s00417-015-2998-y