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Osteoblast physiology in normal and pathological conditions

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Abstract

Osteoblasts are mononucleated cells that are derived from mesenchymal stem cells and that are responsible for the synthesis and mineralization of bone during initial bone formation and later bone remodelling. Osteoblasts also have a role in the regulation of osteoclast activity through the receptor activator of nuclear factor κ-B ligand and osteoprotegerin. Abnormalities in osteoblast differentiation and activity occur in some common human diseases such as osteoporosis and osteoarthritis. Recent studies also suggest that osteoblast functions are compromised at sites of focal bone erosion in rheumatoid arthritis.

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  1. Rheumatology Clinic, Department of Medical and Occupational Sciences, University of Foggia, Foggia, Italy

    Anna Neve, Addolorata Corrado & Francesco Paolo Cantatore

  2. Rheumatology Clinic, University of Foggia, Ospedale “Col. D’Avanzo”, V.le degli Aviatori 1, 71100, Foggia, Italy

    Francesco Paolo Cantatore

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Neve, A., Corrado, A. & Cantatore, F.P. Osteoblast physiology in normal and pathological conditions. Cell Tissue Res 343, 289–302 (2011). https://doi.org/10.1007/s00441-010-1086-1

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