Skip to main content
Erschienen in: Soft Computing 10/2020

14.09.2019 | Methodologies and Application

A machine learning evolutionary algorithm-based formula to assess tumor markers and predict lung cancer in cytologically negative pleural effusions

verfasst von: Stefano Elia, Gianni D’Angelo, Francesco Palmieri, Roberto Sorge, Renato Massoud, Claudio Cortese, Georgia Hardavella, Alessandro De Stefano

Erschienen in: Soft Computing | Ausgabe 10/2020

Einloggen

Aktivieren Sie unsere intelligente Suche um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Malignant pleural effusion is diagnostically challenging in presence of negative cytology. The assessment of tumor markers in serum has become a standard tool in cancer diagnosis, while pleural fluid sampling has not met universal consensus. The evaluation of a panel of markers both in serum and pleural fluid may be crucial to improve the diagnostic accuracy. Using a machine learning-based approach, we provide a mathematical formula capable to express the complex relation existing among the expressed markers in serum and pleural effusion and the presence of lung cancer. The formula indicates CEA and CYFRA21-1 in pleural fluid as the best diagnostic markers, with 97% accuracy, 98% sensitivity, 95% specificity, 96% area under curve, 98% positive predictive value, and 92% MCC (Matthews correlation coefficient).

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Anhänge
Nur mit Berechtigung zugänglich
Literatur
Zurück zum Zitat Alataş F, Alataş O, Metintaş M, Colak O, Harmanci E, Demir S (2001) Diagnostic value of CEA, CA 15–3, CA 19–9, CYFRA 21–1, NSE and TSA assay in pleural effusions. Lung Cancer 31(1):9–16CrossRef Alataş F, Alataş O, Metintaş M, Colak O, Harmanci E, Demir S (2001) Diagnostic value of CEA, CA 15–3, CA 19–9, CYFRA 21–1, NSE and TSA assay in pleural effusions. Lung Cancer 31(1):9–16CrossRef
Zurück zum Zitat Arnold DT, De Fonseka D, Perry S, Morley A, Harvey JE, Medford A, Brett M, Maskell NA (2018) Investigating unilateral pleural effusions: the role of cytology. Eur Respir J 52(5):1801254CrossRef Arnold DT, De Fonseka D, Perry S, Morley A, Harvey JE, Medford A, Brett M, Maskell NA (2018) Investigating unilateral pleural effusions: the role of cytology. Eur Respir J 52(5):1801254CrossRef
Zurück zum Zitat Bennett R, Maskell N (2005) Management of malignant pleural effusions. Curr Opin Pulm Med 11(4):296–300 Bennett R, Maskell N (2005) Management of malignant pleural effusions. Curr Opin Pulm Med 11(4):296–300
Zurück zum Zitat Bibby AC, Maskell NA (2016) Pleural biopsies in undiagnosed pleural effusions; Abrams vs image-guided vs thoracoscopic biopsies. Curr Opin Pulm Med 22(4):392–398CrossRef Bibby AC, Maskell NA (2016) Pleural biopsies in undiagnosed pleural effusions; Abrams vs image-guided vs thoracoscopic biopsies. Curr Opin Pulm Med 22(4):392–398CrossRef
Zurück zum Zitat Davies HE, Sadler RS, Bielsa S, Maskell NA, Rahman NM, Davies RJ, Ferry BL, Lee YC (2009) Clinical impact and reliability of pleural fluid mesothelin in undiagnosed pleural effusions. Am J Respir Crit Care Med 180(5):437–444CrossRef Davies HE, Sadler RS, Bielsa S, Maskell NA, Rahman NM, Davies RJ, Ferry BL, Lee YC (2009) Clinical impact and reliability of pleural fluid mesothelin in undiagnosed pleural effusions. Am J Respir Crit Care Med 180(5):437–444CrossRef
Zurück zum Zitat DeCamp MM, Mentzer SJ, Swanson SJ, Sugarbaker DJ (1997) Malignant effusive disease of the pleura and pericardium. Chest 112(4 Suppl):291S–295SCrossRef DeCamp MM, Mentzer SJ, Swanson SJ, Sugarbaker DJ (1997) Malignant effusive disease of the pleura and pericardium. Chest 112(4 Suppl):291S–295SCrossRef
Zurück zum Zitat Elia S, Massoud R, Guggino G, Cristino B, Cortese C, De Massimi AR, Zenobi R (2008) Tumor type M2-pyruvate-kinase levels in pleural fluid versus plasma in cancer patients: a further tool to define the need for invasive procedures. Eur J Cardiothorac Surg 33(4):723–727CrossRef Elia S, Massoud R, Guggino G, Cristino B, Cortese C, De Massimi AR, Zenobi R (2008) Tumor type M2-pyruvate-kinase levels in pleural fluid versus plasma in cancer patients: a further tool to define the need for invasive procedures. Eur J Cardiothorac Surg 33(4):723–727CrossRef
Zurück zum Zitat Gu P, Huang G, Chen Y, Zhu C, Yuan J, Sheng S (2007) Diagnostic utility of pleural fluid carcinoembryonic antigen and CYFRA 21–1 in patients with pleural effusion: a systematic review and meta-analysis. J Clin Lab Anal 21(6):398–405CrossRef Gu P, Huang G, Chen Y, Zhu C, Yuan J, Sheng S (2007) Diagnostic utility of pleural fluid carcinoembryonic antigen and CYFRA 21–1 in patients with pleural effusion: a systematic review and meta-analysis. J Clin Lab Anal 21(6):398–405CrossRef
Zurück zum Zitat Gu Y, Qiao X, Wang L, Fu X (2017) The diagnostic value of parallel detection of cytokeratin 19 fragment-based tumor markers in malignant pleural effusion: a systematic review and meta-analysis. Biomed Res (India) 28(18):8105–8114 Gu Y, Qiao X, Wang L, Fu X (2017) The diagnostic value of parallel detection of cytokeratin 19 fragment-based tumor markers in malignant pleural effusion: a systematic review and meta-analysis. Biomed Res (India) 28(18):8105–8114
Zurück zum Zitat Heffner JE, Klein JS (2008) Recent advances in the diagnosis and management of malignant pleural effusions. Mayo Clin Proc 83(2):235–250CrossRef Heffner JE, Klein JS (2008) Recent advances in the diagnosis and management of malignant pleural effusions. Mayo Clin Proc 83(2):235–250CrossRef
Zurück zum Zitat Holdenrieder S, Wehnl B, Hettwer K, Simon K, Uhlig S, Dayyani F (2017) Carcinoembryonic antigen and cytokeratin-19 fragments for assessment of therapy response in non-small cell lung cancer: a systematic review and meta-analysis. Br J Cancer 116(8):1037–1045. https://doi.org/10.1038/bjc.2017.45 CrossRef Holdenrieder S, Wehnl B, Hettwer K, Simon K, Uhlig S, Dayyani F (2017) Carcinoembryonic antigen and cytokeratin-19 fragments for assessment of therapy response in non-small cell lung cancer: a systematic review and meta-analysis. Br J Cancer 116(8):1037–1045. https://​doi.​org/​10.​1038/​bjc.​2017.​45 CrossRef
Zurück zum Zitat Kohavi R (1995) A study of cross-validation and bootstrap for accuracy estimation and model selection. In: Proceedings of the 14th international joint conference on artificial intelligence. vol 2, IJCAI’95, pp 1137–1143. Morgan Kaufmann Publishers Inc., San Francisco, CA, USA. http://dl.acm.org/citation.cfm?id=1643031.1643047. Accessed 12 Sept 2019 Kohavi R (1995) A study of cross-validation and bootstrap for accuracy estimation and model selection. In: Proceedings of the 14th international joint conference on artificial intelligence. vol 2, IJCAI’95, pp 1137–1143. Morgan Kaufmann Publishers Inc., San Francisco, CA, USA. http://​dl.​acm.​org/​citation.​cfm?​id=​1643031.​1643047. Accessed 12 Sept 2019
Zurück zum Zitat Korczynski P, Krenke R, Safianowska A, Gorska K, Abou Chaz MB, Maskey-Warzechowska M, Kondracka A, Nasilowski J, Chazan R (2009) Diagnostic utility of pleural fluid and serum markers in differentiation between malignant and non-malignant pleural effusions. Eur J Med Res 14(Suppl 4):128–133. https://doi.org/10.1186/2047-783x-14-s4-128 CrossRef Korczynski P, Krenke R, Safianowska A, Gorska K, Abou Chaz MB, Maskey-Warzechowska M, Kondracka A, Nasilowski J, Chazan R (2009) Diagnostic utility of pleural fluid and serum markers in differentiation between malignant and non-malignant pleural effusions. Eur J Med Res 14(Suppl 4):128–133. https://​doi.​org/​10.​1186/​2047-783x-14-s4-128 CrossRef
Zurück zum Zitat Mitchell M (1998) An introduction to genetic algorithms. MIT Press, CambridgeMATH Mitchell M (1998) An introduction to genetic algorithms. MIT Press, CambridgeMATH
Zurück zum Zitat Shamsaei B, Gao C (2016) Comparison of some machine learning and statistical algorithms for classification and prediction of human cancer type. In: 2016 IEEE-EMBS international conference on biomedical and health informatics (BHI), pp 296–299. https://doi.org/10.1109/BHI.2016.7455893 Shamsaei B, Gao C (2016) Comparison of some machine learning and statistical algorithms for classification and prediction of human cancer type. In: 2016 IEEE-EMBS international conference on biomedical and health informatics (BHI), pp 296–299. https://​doi.​org/​10.​1109/​BHI.​2016.​7455893
Zurück zum Zitat Shitrit D, Zingerman B, Shitrit AB, Shlomi D, Kramer MR (2005) Diagnostic value of CYFRA 21–1, CEA, CA 19–9, CA 15–3, and CA 125 assays in pleural effusions: analysis of 116 cases and review of the literature. Oncologist 10(7):501–507CrossRef Shitrit D, Zingerman B, Shitrit AB, Shlomi D, Kramer MR (2005) Diagnostic value of CYFRA 21–1, CEA, CA 19–9, CA 15–3, and CA 125 assays in pleural effusions: analysis of 116 cases and review of the literature. Oncologist 10(7):501–507CrossRef
Zurück zum Zitat Sriram KB, Relan V, Clarke BE, Duhig EE, Yang IA, Bowman RV, Lee YC, Fong KM (2011) Diagnostic molecular biomarkers for malignant pleural effusions. Future Oncol 7(6):737–752CrossRef Sriram KB, Relan V, Clarke BE, Duhig EE, Yang IA, Bowman RV, Lee YC, Fong KM (2011) Diagnostic molecular biomarkers for malignant pleural effusions. Future Oncol 7(6):737–752CrossRef
Zurück zum Zitat Topolcan O, Holubec L, Polivkova V, Svobodova S, Pesek M, Treska V, Safranek J, Hajek T, Bartunek L, Rousarova M, Finek J (2007) Tumor markers in pleural effusions. Anticancer Res. 27(4A):1921–1924 Topolcan O, Holubec L, Polivkova V, Svobodova S, Pesek M, Treska V, Safranek J, Hajek T, Bartunek L, Rousarova M, Finek J (2007) Tumor markers in pleural effusions. Anticancer Res. 27(4A):1921–1924
Zurück zum Zitat Trape J, Sant F, Franquesa J, Montesinos J, Arnau A, Sala M, Bernadich O, Martin E, Perich D, Perez C, Lopez J, Ros S, Esteve E, Perez R, Aligue J, Gurt G, Catot S, Domenech M, Bosch J, Badal JM, Bonet M, Molina R, Ordeig J (2017) Evaluation of two strategies for the interpretation of tumour markers in pleural effusions. Respir Res 18(1):103. https://doi.org/10.1186/s12931-017-0582-1 CrossRef Trape J, Sant F, Franquesa J, Montesinos J, Arnau A, Sala M, Bernadich O, Martin E, Perich D, Perez C, Lopez J, Ros S, Esteve E, Perez R, Aligue J, Gurt G, Catot S, Domenech M, Bosch J, Badal JM, Bonet M, Molina R, Ordeig J (2017) Evaluation of two strategies for the interpretation of tumour markers in pleural effusions. Respir Res 18(1):103. https://​doi.​org/​10.​1186/​s12931-017-0582-1 CrossRef
Zurück zum Zitat Yang Y, Liu YL, Shi HZ (2017) Diagnostic accuracy of combinations of tumor markers for malignant pleural effusion: an updated meta-analysis. Respiration 94(1):62–69CrossRef Yang Y, Liu YL, Shi HZ (2017) Diagnostic accuracy of combinations of tumor markers for malignant pleural effusion: an updated meta-analysis. Respiration 94(1):62–69CrossRef
Metadaten
Titel
A machine learning evolutionary algorithm-based formula to assess tumor markers and predict lung cancer in cytologically negative pleural effusions
verfasst von
Stefano Elia
Gianni D’Angelo
Francesco Palmieri
Roberto Sorge
Renato Massoud
Claudio Cortese
Georgia Hardavella
Alessandro De Stefano
Publikationsdatum
14.09.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Soft Computing / Ausgabe 10/2020
Print ISSN: 1432-7643
Elektronische ISSN: 1433-7479
DOI
https://doi.org/10.1007/s00500-019-04344-1

Weitere Artikel der Ausgabe 10/2020

Soft Computing 10/2020 Zur Ausgabe