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Radiological outcome of tibial plateau fractures treated with percutaneously introduced synthetic porous Hydroxyapatite granules

Fractures du plateau tibial traitées par introduction percutanée de granules HAP

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European Journal of Orthopaedic Surgery & Traumatology Aims and scope Submit manuscript

Abstract

Synthetic bone-graft substitutes are increasingly being used in clinical orthopaedic practice. In India, Sree Chitra Tirunal Institute of Medical Sciences and Technology has pioneered the research and development of indigenous ceramic bone substitutes. The Chitra HAP is a synthetic porous Hydroxyapatite that has completed pre-market trials according to prescribed format and has also undergone limited clinical trials in humans. This study is a clinical trial to ascertain the use of the product in the treatment of cancellous impaction fractures. Twenty-eight tibial plateau fractures were treated by a standard surgical protocol using the HAP for cancellous bone augmentation. The results were evaluated by serial radiography at specified intervals up to 1 year. At 1 year the HAP appeared fully integrated with the host bone radiologically and the articular subsidence had ceased. The synthetic HAP remained radio-opaque even at 1 year. No adverse effects were noticed due to the synthetic material. It was concluded that Chitra porous HAP is a safe and useful bone graft substitute for cancellous bone augmentation in fractures.

Résumé

Les substituts osseux sont de plus en plus employés dans la pratique orthopédique ou traumatologique. L’Institut des Sciences et de la Technologie Médicales de Sree Chitra Thirunal (Inde) a initié la recherche et le développement d’un substitut osseux. Le Chitra-HAP est une hydroxyapatite poreuse synthétique qui a satisfait aux épreuves de pré-market selon les normes définies et a également été utilisé dans des essais cliniques limités chez l’homme. Cette étude a pour objet de valider l’utilisation du produit dans le traitement des fractures du plateau tibial externe avec tassement. Vingt huit fractures ont été traitées selon un protocole chirurgical standard en utilisant le Chitra-HAP pour combler la perte d’os spongieux. Les résultats ont été évalués par radiographie à intervalles réguliers jusqu’à 1 an. A un an, le Chitra-HAP semble radiologiquement entièrement intégré à l’os hôte et on n’observe pas d’enfoncement articulaire. Le Chitra-HAP synthétique reste radio-opaque même à un an. Aucun effet secondaire n’a été relevé. On peut conclure que le Chitra-HAP est un substitut de remplacement sûr et efficace pour combler les pertes de substance d’os spongieux dans les fractures du plateau tibial externe.

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Authors and Affiliations

  1. Department of Orthopaedics, Amrita Institute of Medical Sciences and Research Centre, Edappally, Cochin 26, Kerala, 682026, India

    K. V. Menon

  2. Bioceramic laboratory, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojappura, Trivandrum, Kerala, 695012, India

    H. K. Varma

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  1. K. V. Menon
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Correspondence to K. V. Menon.

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Menon, K.V., Varma, H.K. Radiological outcome of tibial plateau fractures treated with percutaneously introduced synthetic porous Hydroxyapatite granules. Eur J Orthop Surg Traumatol 15, 205–213 (2005). https://doi.org/10.1007/s00590-005-0238-6

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  • DOI: https://doi.org/10.1007/s00590-005-0238-6

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