Skip to main content

Advertisement

SpringerLink
Log in

Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation: Report of a case

  • Case Report
  • Published:
Surgery Today Aims and scope Submit manuscript

Abstract

Myocardial regeneration therapy shows great promise as a treatment for heart failure. We recently introduced combined autologous cellular cardiomyoplasty with skeletal myoblasts and bone marrow cells as a treatment for human ischemic cardiomyopathy. We report the results of our first clinical trial of this technique, used to treat a patient with severe heart failure caused by ischemic cardiomyopathy who was being managed with a left ventricular assist system (LVAS). After combined cell transplantation, the patient showed signs of improved cardiac performance and angiogenesis, and reduced fibrosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Dib N, Michler RE, Pagani FD, Wright S, Kereiakes DJ, Lengerich R, et al. Safety and feasibility of autologous myoblast transplantation in patients with ischemic cardiomyopathy: four-year followup. Circulation 2005;112(12):1748–1755.

    Article  PubMed  Google Scholar 

  2. Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, Mesquita CT, et al. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 2003;107(18):2294–2302.

    Article  PubMed  Google Scholar 

  3. Miyagawa S, Sawa Y, Taketani S, Kawaguchi N, Nakamura T, Matsuura N, et al. Myocardial regeneration therapy for heart failure: hepatocyte growth factor enhances the effect of cellular cardiomyoplasty. Circulation 2002;105(21):2556–2561.

    Article  PubMed  CAS  Google Scholar 

  4. Memon IA, Sawa Y, Miyagawa S, Taketani S, Matsuda H. Combined autologous cellular cardiomyoplasty with skeletal myoblasts and bone marrow cells in canine hearts for ischemic cardiomyopathy. J Thorac Cardiovasc Surg 2005;130(3):646–653.

    Article  PubMed  Google Scholar 

  5. Tateishi-Yuyama E, Matsubara H, Murohara T, Ikeda U, Shintani S, Masaki H, et al. Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial. Lancet 2002;10;360(9331):427–435.

    Article  PubMed  Google Scholar 

  6. Ishii K, Miwa K, Makita T, Okuda N. Prolonged postischemic regional left ventricular delayed relaxation or diastolic asynchrony detected by color kinesis following coronary vasospasm. Am J Cardiol 2003;91(11):1366–1369.

    Article  PubMed  Google Scholar 

  7. Mancini DM, Beniaminovitz A, Levin H, Catanese K, Flannery M, DiTullio M, et al. Low incidence of myocardial recovery after left ventricular assist device implantation in patients with chronic heart failure. Circulation 1998;98:2383–2389.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Shigeru Miyagawa, Goro Matsumiya, Toshihiro Funatsu, Masao Yoshitatsu, Naozumi Sekiya, Shinya Fukui, Takaya Hoashi & Yoshiki Sawa

  2. Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Masatsugu Hori

  3. Department of Orthopedics, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Hideki Yoshikawa

  4. Department of Hematology and Oncology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Yuzuru Kanakura & Jun Ishikawa

  5. Department of Pathology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Katsuyuki Aozasa

  6. Department of Pathology, School of Allied Health Science, Faculty of Medicine, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Naomasa Kawaguchi & Nariaki Matsuura

  7. Medical Center for Translational Research, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan

    Akira Myoui, Akifumi Matsuyama & Sachiko Ezoe

  8. Department of Investigative Radiology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan

    Hidehiro Iida

  9. Department of Cardiovascular Surgery, Hyogo Medical College, Nishinomiya, Hyogo, Japan

    Hikaru Matsuda

Authors
  1. Shigeru Miyagawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Goro Matsumiya
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Toshihiro Funatsu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Masao Yoshitatsu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Naozumi Sekiya
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Shinya Fukui
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Takaya Hoashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Masatsugu Hori
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Hideki Yoshikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Yuzuru Kanakura
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Jun Ishikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Katsuyuki Aozasa
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Naomasa Kawaguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Nariaki Matsuura
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Akira Myoui
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Akifumi Matsuyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Sachiko Ezoe
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. Hidehiro Iida
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. Hikaru Matsuda
    View author publications

    You can also search for this author in PubMed Google Scholar

  20. Yoshiki Sawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Miyagawa, S., Matsumiya, G., Funatsu, T. et al. Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation: Report of a case. Surg Today 39, 133–136 (2009). https://doi.org/10.1007/s00595-008-3803-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00595-008-3803-x

Key words

Search

Navigation