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Serotonin sensor based on a glassy carbon electrode modified with multiwalled carbon nanotubes, chitosan and poly(p-aminobenzenesulfonate)

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Abstract

A glassy carbon electrode was modified with a nanocomposite prepared from poly(p-aminobenzene sulfonic acid), multi-walled carbon nanotubes and chitosan to obtain a differential pulse voltammetric sensor for serotonin that is remarkably stable and displays enhanced current response. Its peak current (at 0.38 V vs. Ag/AgCl) varied linearly with the concentration of serotonin in the 0.1–100 μM range, and the detection limit is 80 nM (at an S/N of 3). The sensor was successfully applied to the determination of serotonin in (spiked) human blood serum.

An electrode modified with MWCNTs, chitosan and poly(p-aminobenzene sulfonate) gives significantly enhanced signals for serotonin and improves its oxidation peak current as shown in plot (d) due to improved direct electron transfer.

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Acknowledgments

The authors gratefully acknowledge financial support of this study by Key Laboratory of Water Environment Evolution and Pollution Control in Three Gorges Reservoir fund project (no.WEPKL2013QN-02)

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Authors and Affiliations

  1. Key Laboratory of Water Environment Evolution and Pollution Control in Three Gorges Reservoir, Chongqing Three Georges University, Wanzhou, 404100, People’s Republic of China

    Gu Ran, Chuanning Chen & Chuan Gu

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  1. Gu Ran
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  2. Chuanning Chen
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  3. Chuan Gu
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Correspondence to Gu Ran.

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Ran, G., Chen, C. & Gu, C. Serotonin sensor based on a glassy carbon electrode modified with multiwalled carbon nanotubes, chitosan and poly(p-aminobenzenesulfonate). Microchim Acta 182, 1323–1328 (2015). https://doi.org/10.1007/s00604-015-1454-3

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  • DOI: https://doi.org/10.1007/s00604-015-1454-3

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