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Evaluation of the limit of performance of an analytical method based on a statistical calculation of its critical concentrations according to ISO standard 11843: Application to routine control of banned veterinary drug residues in food according to European Decision 657/2002/EC

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An Erratum to this article was published on 29 November 2006

Abstract

Traceability of the measurement of analytical parameters capable of evaluating the performance of methods is an important concept for the assessment of quality for the routine control, especially for residue monitoring of non-authorized medicinal substances in food from animal origin. The European Decision no. 657/2002/EC recommends to calculate two statistical limits, CCα and CCβ, which allow to evaluate the critical concentrations above which the method reliably distinguish and quantify a substance taking into account the variability of the method and the statistical risk to take a wrong decision. The calculation, which can be derived from the ISO standard no. 11843 is applied on a routine basis. An example displays a very simple way for evaluating the performance of an LC-MSMS method which has been validated a few years ago and is qualified onto a Micromass Quattro LCZ tandem mass spectrometer to monitor and confirm the nitrofuran metabolite residues in food from animal origin.

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References

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Authors and Affiliations

  1. AFSSA, Laboratoire d’Etudes et de Recherches sur les Médicaments Vétérinaires et les Désinfectants - BP 90230, 35302, Fougères, France

    E. Verdon, D. Hurtaud-Pessel & P. Sanders

Authors
  1. E. Verdon
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  2. D. Hurtaud-Pessel
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  3. P. Sanders
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Correspondence to E. Verdon.

Additional information

Presented at the 3rd AOAC Europe/Eurachem Symposium: “Legal limits on the road to food safety: establishing sound criteria for compliance decisions”, 3–4 March 2005, Brussels, Belgium.

Community Reference Laboratory for Antimicrobial Veterinary Drug Residue Control in Food from Animal Origin

An erratum to this article is available at http://dx.doi.org/10.1007/s00769-006-0218-5.

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Verdon, E., Hurtaud-Pessel, D. & Sanders, P. Evaluation of the limit of performance of an analytical method based on a statistical calculation of its critical concentrations according to ISO standard 11843: Application to routine control of banned veterinary drug residues in food according to European Decision 657/2002/EC. Accred Qual Assur 11, 58–62 (2006). https://doi.org/10.1007/s00769-005-0055-y

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