Abstract
A design methodology for micromixers is presented which systematically integrates computational fluid dynamics (CFD) with an optimization methodology based on the use of design of experiments (DOE), function approximation technique (FA) and multi-objective genetic algorithm (MOGA). The methodology allows the simultaneous investigation of the effect of geometric parameters on the mixing performance of micromixers whose design strategy is based fundamentally on the generation of chaotic advection. The methodology has been applied on a Staggered Herringbone Micromixer (SHM) at several Reynolds numbers. The geometric features of the SHM are optimized and their effects on mixing are evaluated. The degree of mixing and the pressure drop are the performance criteria to define the efficiency of the micromixer for different design requirements.
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Abbreviations
- CFD:
-
Computational fluids dynamics
- DOE:
-
Design of experiments
- FA:
-
Function approximation technique
- MEMS:
-
Micro-electromechanical systems
- MOGA:
-
Multi-objective genetic algorithm
- NSGA-II:
-
Non-dominated sorting genetic algorithm II
- RBF:
-
Radial basis function
- RBNN:
-
Radial basis neural network
- RSM:
-
Response surface method
- SHM:
-
Staggered Herringbone Mixer
- SPEA2:
-
Strength pareto evolutionary algorithm 2
- SQP:
-
Sequential Quadratic Programming
- OA:
-
Orthogonal array
- PF:
-
Pareto Front
- M i :
-
mixing index
- C :
-
local (area element) value of the concentration (mass fraction) of one fluid species
- c i :
-
concentration distribution of one of the fluids species at the ith mesh cell on the outlet plane
- c 0 :
-
local concentration at the inlet of the mixing channel
- c ∞ :
-
concentration of complete mixing (mixing steady-state concentration)
- A :
-
cross section plane in the mixing channel
- A 0 :
-
inlet section or plane of the mixing channel
- N :
-
number of cells defined by the mesh on the outlet plane
- W :
-
width of the mixing channel (μm)
- H :
-
height of the mixing channel plus half the depth of a groove (μm)
- h m :
-
height of the mixing channel (μm)
- w g :
-
width of the groove (μm)
- d g :
-
depth of the groove (μm)
- b :
-
asymmetry factor, b ≥ 0.5
- N g :
-
number of grooves per half cycle
- U :
-
upstream (inlet) channel width (μm)
- Re :
-
Reynolds number
- S/N :
-
signal-to-noise ratio
- P :
-
gauge pressure (Pa)
- P j :
-
performance parameter
- X j :
-
design parameter
- N :
-
number of designs parameters
- M :
-
number of performance parameters
- a 0 , a i , a ii , a ij :
-
coefficients of the polynomial function given by RSM
- R 2, R 2adj :
-
accuracy factors of surface models
- α :
-
groove depth ratio, d g /2h
- α′:
-
ratio of groove depth to mixing channel height
- γ :
-
acute angle formed by a groove and the channel axis (°)
- θ :
-
groove intersection angle (°)
- λ :
-
groove pitch (μm)
- η :
-
signal-to-noise ratio
- σ 2 :
-
square of Standard deviation
- \( \mu_{{{\text{H}}_{2} {\text{O}}}} \) :
-
dynamic viscosity of water (kg m−1 s−1)
- \( \rho_{{{\text{H}}_{2} {\text{O}}}} \) :
-
density of water (kg m−3)
- \( \mu_{{{\text{C}}_{2} {\text{H}}_{60} }} \) :
-
dynamic viscosity of ethanol (kg m−1 s−1)
- \( \rho_{{{\text{C}}_{2} {\text{H}}_{60} }} \) :
-
density of ethanol (kg m−3)
References
Ansari MA, Kim K-Y (2007a) Application of the Radial Basis Neural Network to Optimization of a Micromixer. Chem Eng Technol 30(7):962–966
Ansari MA, Kim K-Y (2007b) Shape optimization of a micromixer with staggered herringbone groove. Chem Eng Sci 62:6687–6695
ANSYS Europe Ltd (2005) CFX 10.0 User manual
Aubin J, Fletcher DF, Bertrand J, Xuereb C (2003) Characterization of the mixing quality in micromixers. Chem Eng Technol 26(12):1262–1270
Aubin J, Fletcher DF, Xuereb C (2005) Design of micromixers using CFD modelling. Chem Eng Sci 60(8–9):2503–2516
Bonaiuti D, Zangeneh M (2006) On the coupling of inverse design and optimization techniques for turbomachinery blade design. ASME Paper GT2006-90897. To be published in ASME J. Of Turbomachinery
Bothe D, Stemich C, Warnecke H-J (2006) Fluid mixing in a T-shaped micro-mixer. Chem Eng Sci 61:2950–2958
Deb K (2001) Multi-objective optimization using evolutionary algorithms. Wiley, Chichester
Deb K, Agrawal A, Pratap T, Meyarivan T (2000) A fast and elitist multi-objective genetic algorithm for multi-objective optimization: NSGA-II. In: Proceedings of the parallel problem solving from nature VI conference, Paris, France, pp 849–858
Engineous Software Inc (2006) iSIGHT-FD user’s guide, version 2.0
Goldberg DE (1989) Genetic algorithms in search, optimization and machine learning. Addison-Wesley, Reading
Hardy RL (1971) Multiquadric equations of topography and other irregular surfaces. J Geophysics Res 176:1905–1915
Hardy RL (1990) Theory and applications of the multiquadric-biharmonic method: 20 years of discovery. Comput Math Applic 19(8/9):163–208
Hassel DG, Zimmerman WB (2006) Investigation of the convective motion through a staggered herringbone micromixer at low Reynolds number flow. Chem Eng Sci 61:2977–2985
Ivorra B, Hertzog DE, Mohammadi B, Santiago JG (2006) Semi-deterministic and genetic algorithms for global optimization of microfluidic protein-folding devices. Int J Numer Method Eng 66:319–333
Kang TG, Kwon TH (2004) Colored particle tracking method for mixing analysis of chaotic micromixers. J Micromech Microeng 14(7):891–899
Kang TG, Singh MK, Kwon TH, Anderson PD (2008) Chaotic mixing using periodic and aperiodic sequences of mixing protocols in a micromixer. Microfluid Nanofluid 4(6):589–599
Kansa EJ (1999) Motivation for using radial basis function to solve PDE’s (unpublished paper), in http://rbf-pde.uah.edu/kansaweb.html, accessed on Aug 22nd, 2007
Li C, Chen T (2005) Simulation and optimization of chaotic micromixer using lattice Boltzmann method. Sens Actuators B 106:871–877
Liu YZ, Kim BJ, Sung HJ (2004) Two-fluid mixing in a microchannel. Int J Heat Fluid Flow 25:986–995
Lynn NS, Dandy DS (2007) Geometrical optimization of helical flow in grooved micromixers. Lab Chip 7:580–587
Mott DR, Howell PB Jr, Golden JP, Kaplan CR, Ligler FS, Oran ES (2006) Toolbox for the design of optimized microfluidic components. Lab Chip 6:540–549
Müller SD, Mezić I, Walther JH, Koumoutsakos P (2004) Transverse momentum micromixer optimization with evolution strategies. Comput Fluids 33:521–531
Myers RH (1999) Response surface methodology—current status and future direction. J Qual Technol 31(1):30–74
Myers RH, Montgomery DC (1995) Response surface methodology: process and product optimization using designed experiment. Wiley, New York
Nguyen N, Wu Z (2005) Micromixers-a review. J Micromech Microeng 15:R1–R16
Pointwise Inc (2006) Gridgen 15.1 user manual
Singh MK, Kang TG, Meijer HEH, Anderson PD (2008) The mapping method as a toolbox to analyze, design and optimize micromixers. Microfluid Nanofluid 5(3):313–325
Stroock AD, McGraw GJ (2004) Investigation of the staggered herringbone mixer with a simple analytical model. Philos Trans Royal Soc London Ser A 362(1818):971–986
Stroock AD, Dertinger SKW, Ajdari A, Mezić I, Stone HA, Whitesides GM (2002) Chaotic mixer for microchannels. Science 295:647–651
Taguchi G (1987) Systems of Experimental Design, Vols. 1 and 2. Kraus International, New York
Taguchi G, Chowdhury S, Taguchi S (1999) Robust engineering. McGraw-Hill, New York
Vanderplaats GN (1984) Numerical optimization techniques for engineering design: with applications. McGraw-Hill , New York
Yang J-T, Huang K-J, Lin Y-C (2005) Geometric effects on fluid mixing in passive grooved micromixers. Lab Chip 5(10):1140–1147
Yiu C, Zangeneh M (2000) A 3D Automatic Optimization Method for Turbomachinery Blade Design. AIAA J Propul Power 16(6):1174–1181
Zitzler E, Laumanns M, Thiele L (2001) SPEA2: Improving the performance of the Strength Pareto Evolutionary Algorithm. Technical Report No. 103, Computer Engineering and Communication Networks Laboratory (TIK), Swiss Federal Institute of Technology (ETH), Zurich, Switzerland
Acknowledgments
This work was supported by a Dorothy Hodgkin Postgraduate Award (DHPA) of the United Kingdom and by Ebara Research Co. Ltd. of Japan.
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Cortes-Quiroz, C.A., Zangeneh, M. & Goto, A. On multi-objective optimization of geometry of staggered herringbone micromixer. Microfluid Nanofluid 7, 29–43 (2009). https://doi.org/10.1007/s10404-008-0355-8
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DOI: https://doi.org/10.1007/s10404-008-0355-8