Skip to main content
Log in

Continuous and Noninvasive Blood Pressure Measurement: A Novel Modeling Methodology of the Relationship Between Blood Pressure and Pulse Wave Velocity

  • Published:
Annals of Biomedical Engineering Aims and scope Submit manuscript

Abstract

In this paper, we aim to establish a new mathematical model that relates pulse wave velocity (PWV) to blood pressure (BP) for continuous and noninvasive BP measurement. For the first time, we derive an ordinary differential equation (ODE) expressing the fundamental relation between BP, elastic modulus G and PWV. The general solution of this ODE is the mathematical BP-PWV model. In our model, the elastic modulus G is included in model parameters, unlike the existing theoretical models. This enables us to express the BP-PWV relationship for subjects of different ages and genders. A family of BP-PWV functions for specific age and gender groups can be obtained using statistical methods based on clinical trial data, which serve as the calibrated benchmark models for continuous and noninvasive BP measurement. To illustrate the modeling methodology, we construct benchmark models for people aged 19 and 60 and apply them to continuous diastolic blood pressure (DBP) measurement without individual calibration. The results of clinical tests meet the test standard in ANSI/AAMI SP10, which attests the feasibility of the modeling methodology.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9

Similar content being viewed by others

References

  1. Chen, W., T. Kobayashi, S. Ichikawa, Y. Takeuchi, and T. Togawa. Continuous estimation of systolic blood pressure using the pulse arrival time and intermittent calibration. Med. Biol. Eng. Comput. 38:569–574, 2000.

    Article  PubMed  CAS  Google Scholar 

  2. Chen, Y., C. Wen, H. Tang, and X. Teng. The relationship between different pulse wave velocity and systolic/diastolic pressure. The 3rd IEEE Conference on Industrial Electronics and Applications, Singapore, 2008.

  3. Chua, C. P., and C. Heneghan. Continuous blood pressure monitoring using ECG and finger photoplethysmogram. The 28th IEEE EMBS Annual International Conference, New York, 2006.

  4. Fung, P., G. Dumont, C. Ries, C. Mott, and M. Ansermino. Continuous noninvasive blood pressure measurement by pulse transit time. The 26th Annual International Conference of the IEEE EMBS, San Francisco, CA, 2004.

  5. Hughes, D. J., C. F. Babbs, L. A. Geddes, and J. D. Bourland. Measurement of Young’s modulus of elasticity of the canine aorta with ultrasound. Ultrason. Imaging 1:356–367, 1979.

    Article  PubMed  CAS  Google Scholar 

  6. Kaniusas, E., H. Pfützner, L. Mehnen, J. Kosel, and J. C. Téllez-Blanco. Method for continuous nondisturbing monitoring of blood pressure by magnetoelastic skin curvature sensor and ECG. IEEE Sens. J. 6:819–828, 2006.

    Article  Google Scholar 

  7. Lass, J., K. Meigas, D. Karai, R. Kattai, J. Kaik, and M. Rossmann. Continuous blood pressure monitoring during exercise using pulse wave transit time measurement. The 26th Annual International Conference of the IEEE EMBS, 2004.

  8. Mei, C. C. Pulse Wave Propagation in Arteries. MIT’s (Massachusetts Institute of Technology) OpenCourseWare, 2004.

  9. Muehlsteff, J., X. L. Aubert, and M. Schuett. Cuffless estimation of systolic blood pressure for short effort bicycle tests: the prominent role of the pre-ejection period. The 28th IEEE EMBS Annual International Conference, New York, 2006.

  10. Poon, C. C. Y., and Y. T. Zhang. Cuff-less and noninvasive measurements of arterial blood pressure by pulse transit time. The 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference, Shanghai, China, 2005.

  11. Poon, C. C. Y., and Y. T. Zhang. The beat-to-beat relationship between pulse transit time and systolic blood pressure. The 5th International Conference on Information Technology and Application in Biomedicine, Shenzhen, China, 2008.

  12. Shaltis, P., A. Reisner, and H. Asada. Calibration of the photoplethysmogram to arterial blood pressure: capabilities and limitations for continuous pressure monitoring. The 2005 IEEE Engineering in Medicine and Biology, Shanghai, China, 2005.

  13. Shi, Y., and N. Deng. Human Circulatory System and Anaesthesiology. Beijing: China Medical Scientific Press, 1990.

    Google Scholar 

  14. Wang, H., and Z. Wen. Mechanics of Blood Circulation, 1990, pp. 83–84, 93–94.

  15. Wong, M. Y. M., C. C. Y. Poon, and Y. T. Zhang. Can the timing-characteristics of phonocardiographic signal be used for cuffless systolic blood pressure estimation? The 28th IEEE EMBS Annual International Conference, New York, 2006.

  16. Zhang, Z. B., and T. H. Wu. The techniques of non-invasive blood pressure measurement and its development. Chin. J. Med. Instrum. 27:196–199, 2003.

    Google Scholar 

Download references

Acknowledgments

This work was supported partly by the Southwest hospital of Chongqing in China. The authors are thankful to the staffs in anesthesiology department for facilitating contacts that made this work possible. Also the authors would like to express their sincere appreciation to the reviewers for their constructive comments and suggestions.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Changyun Wen.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chen, Y., Wen, C., Tao, G. et al. Continuous and Noninvasive Blood Pressure Measurement: A Novel Modeling Methodology of the Relationship Between Blood Pressure and Pulse Wave Velocity. Ann Biomed Eng 37, 2222–2233 (2009). https://doi.org/10.1007/s10439-009-9759-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10439-009-9759-1

Keywords

Navigation