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Regeneration of Diabetic Foot Ulcers Based on Therapy with Red LED Light and a Natural Latex Biomembrane

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Abstract

This study analyzes the effects of the Rapha® system, which employs red light therapy (RLT) and a natural latex biomembrane in the healing of neuropathic ulcers associated with the diabetic foot. We conducted a randomized, controlled, blinded clinical trial with 15 participants that were divided into three groups (GI, GII and GIII): (i) Rapha® system application by the participant and a health professional at home, with clinical status evaluation every 2 weeks at the hospital (GI); (ii) standard protocol used in Brazil, performed by a health professional at the hospital (GII; control); and (iii) the Rapha® system applied by the participant at home and clinical status evaluation every 2 weeks at the hospital (GIII). We used image processing techniques on photographic recordings of the lesions, and several statistical tests were used to analyze the data, allowing for the comparison of the average results for all groups. The average healing rates of GI, GII, and GIII were 77.0, 51.4, and 80%, respectively. The granulation tissue evaluation indicated a higher efficacy in the tissue repair of lesions treated with the Rapha® system. In conclusion, the Rapha® system proved to be an effective healing system, even when self-applied at the patient’s home.

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Acknowledgments

This research was supported by the Ministry of Health of Brazil (CNPq). Funding was provided by Ministry of Health Brazil (Grant No. TC 128 e TC 129), Coordenação de Aperfeicoamento de Pessoal de Nível Superior (scholarship), Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR) (PQ), Conselho Nacional de Desenvolvimento Científico e Tecnológico (DT - Level 2).

Conflict of interest

The following authors have intellectual property claims related to the work: S. S. R. F. Rosa, M. F. F. Rosa, and A. F. da Rocha.

Author information

Authors and Affiliations

  1. Biomedical Engineering Program, Faculty of Gama, Brasília, DF, 72.444-240, Brazil

    S. S. R. F. Rosa

  2. Pos Doc Health Sciences and Technologies - Postgraduate Program in Health Sciences and Technologies of the Faculty of Ceilândia, University of Brasilia, Ceilândia, DF, 72.220-275, Brazil

    M. F. F. Rosa

  3. Biomedical Engineering Program, Faculty of Gama, University of Brasilia, Brasília, DF, 72.444-240, Brazil

    M. P. Marques, G. A. Guimarães, B. C. Motta, Y. C. L. Macedo & P. Inazawa

  4. Postgraduate Program in Health Sciences and Technologies of the Faculty of Ceilândia, University of Brasilia, Ceilândia, DF, 72.220-275, Brazil

    A. Dominguez

  5. Medical Sciences Program, Faculty of Medicine, University of Brasilia, Brasília, DF, 70.910-900, Brazil

    F. S. Macedo

  6. Department of Cell Biology, Institute of Biology, University of Brasilia, Brasília, DF, 70.910-900, Brazil

    C. A. P. Lopes

  7. Electronics and Automation Systems Engineering Program, Department of Electrical Engineering, Brasília, DF, 70.910-900, Brazil

    A. F. da Rocha

  8. Colina Bloco H Apt.408, Campus Universitário Darcy Ribeiro, Asa Norte, Brasília, DF, CEP: 70904-108, Brazil

    S. S. R. F. Rosa

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  1. S. S. R. F. Rosa
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Corresponding author

Correspondence to S. S. R. F. Rosa.

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Associate Editor Stefan M. Duma oversaw the review of this article.

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Rosa, S.S.R.F., Rosa, M.F.F., Marques, M.P. et al. Regeneration of Diabetic Foot Ulcers Based on Therapy with Red LED Light and a Natural Latex Biomembrane. Ann Biomed Eng 47, 1153–1164 (2019). https://doi.org/10.1007/s10439-019-02220-5

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  • DOI: https://doi.org/10.1007/s10439-019-02220-5

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