Abstract
This pilot study tested the efficacy of an audio–visual stimulation (AVS) program for the promotion of sleep in individuals with chronic pain. Insomnia and chronic pain are common comorbid conditions and their relationship has been viewed as bidirectional. Recent studies suggest a relatively dominant role of sleep in this dyad. The premise of this pilot study was that AVS enhances low frequency while reducing high frequency brain activity resulting in decreased hyperarousal and improved sleep with potential consequent reduction in pain. We conducted a pilot intervention study of AVS using a pre–post design. Participants self-administered a 30-min AVS program nightly at bedtime for 1 month. Sleep and pain were assessed at baseline and at the conclusion of the 4-week intervention phase. Nine adults (mean age 33 ± 15.8 years; female, 89 %) completed the study. After using the AVS device for 4 weeks, significant improvement was seen in reported insomnia (ISI, p = 0.003), pain severity (BPI, p = 0.005), and pain interference with functioning (BPI, p = 0.001). Large effect sizes (Partial η2 0.20–0.94) (Cohen’s d 0.44–1.45) were observed. The results of this pilot study suggest that the AVS program may be efficacious in decreasing both insomnia and pain symptoms. In order to better assess the efficacy of AVS for sleep promotion and possible pain reduction, more definitive randomized controlled trials will be needed. These should include appropriate sample sizes, objective measures of sleep and pain, and longitudinal follow-up.
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Adrian, E., & Matthews, B. (1934). The Berger rhythm: Potential changes from the occipital lobes of man. Brain, 57, 355–385.
Alsaadi, S. M., McAuley, J. H., Hush, J. M., Lo, S., Bartlett, D. J., Grunstein, R. R., et al. (2014). The bidirectional relationship between pain intensity and sleep disturbance/quality in patients with low back pain. Clinical Journal of Pain,. doi:10.1097/ajp.0000000000000055.
Bartley, S. (1937). Some observations on the organization of the retinal response. American Journal of Physiology, 120, 184–189.
Bastien, C. H., Vallieres, A., & Morin, C. M. (2001). Validation of the insomnia severity index as an outcome measure for insomnia research. Sleep Medicine, 2(4), 297–307.
Budzynski, T. (1992). Clinical considerations of sound/light. Seattle, WA: Synetics.
Budzynski, T., Budzynski, H., Sherlin, L., & Tang, H. Y. (2011). Audio–visual stimulation: Research and clinical practice. In J. Berger & G. Turow (Eds.), Music, science, and the rhythmic brain (pp. 137–153). New York: Routledge.
Buysse, D. J., Germain, A., Hall, M., Monk, T. H., & Nofzinger, E. A. (2011). A neurobiological model of insomnia. Drug Discovery Today: Disease Models, 8(4), 129–137. doi:10.1016/j.ddmod.2011.07.002.
Cleeland, C. S., & Ryan, K. M. (1994). Pain assessment: Global use of the Brief Pain Inventory. Annals of the Academy of Medicine, Singapore, 23(2), 129–138.
Collura, T., & Siever, D. (2008). Audio–visual entainment in relation to mental health and EEG. In T. Budzynski, H. Budzynski, J. Evans, & A. Abarbanel (Eds.), Introduction to quantitative EEG and neurofeedback: Advanced theory and applications (2nd ed., pp. 193–223). Boston: Elsevier.
Finan, P. H., Goodin, B. R., & Smith, M. T. (2013). The association of sleep and pain: An update and a path forward. The Journal of Pain, 14(12), 1539–1552. doi:10.1016/j.jpain.2013.08.007.
Haack, M., Scott-Sutherland, J., Santangelo, G., Simpson, N. S., Sethna, N., & Mullington, J. M. (2012). Pain sensitivity and modulation in primary insomnia. European Journal of Pain, 16(4), 522–533. doi:10.1016/j.ejpain.2011.07.007.
Hauri, P. (1981). Treating psychophysiologic insomnia with biofeedback. Archives of General Psychiatry, 38(7), 752–758.
Hauri, P. J., Percy, L., Hellekson, C., Hartmann, E., & Russ, D. (1982). The treatment of psychophysiologic insomnia with biofeedback: A replication study. Biofeedback and Self-Regulation, 7(2), 223–235.
Hutchison, Michael. (1990). The megabrain report special issue on sound and light technologies Megabrain Report (Vol. 1). Sausalito, CA: Megabrain Inc.
Jansson-Frojmark, M., & Boersma, K. (2012). Bidirectionality between pain and insomnia symptoms: A prospective study. British Journal of Health Psychology, 17(2), 420–431. doi:10.1111/j.2044-8287.2011.02045.x.
Jasper, H. H. (1936). Cortical excitatory state and synchronism in the control of bioelectric autonomous rhythms. Cold Spring Harbor Symposia on Quantitative Biology, 4, 320–332. doi:10.1101/sqb.1936.004.01.033.
Johannes, C. B., Le, T. K., Zhou, X., Johnston, J. A., & Dworkin, R. H. (2010). The prevalence of chronic pain in United States adults: Results of an Internet-based survey. The Journal of Pain, 11(11), 1230–1239. doi:10.1016/j.jpain.2010.07.002.
Jungquist, C. R., O’Brien, C., Matteson-Rusby, S., Smith, M. T., Pigeon, W. R., Xia, Y., et al. (2010). The efficacy of cognitive–behavioral therapy for insomnia in patients with chronic pain. Sleep Medicine, 11(3), 302–309. doi:10.1016/j.sleep.2009.05.018.
Jungquist, C. R., Tra, Y., Smith, M. T., Pigeon, W. R., Matteson-Rusby, S., Xia, Y., et al. (2012). The durability of cognitive behavioral therapy for insomnia in patients with chronic pain. Sleep Disorders, 2012, 679648. doi:10.1155/2012/679648.
Keller, S., Bann, C. M., Dodd, S. L., Schein, J., Mendoza, T. R., & Cleeland, C. S. (2004). Validity of the brief pain inventory for use in documenting the outcomes of patients with noncancer pain. Clinical Journal of Pain, 20(5), 309–318.
Kroenke, K., Spitzer, R. L., & Williams, J. B. (2001). The PHQ-9: Validity of a brief depression severity measure. Journal of General Internal Medicine, 16(9), 606–613.
Lusa, S., Miranda, H., Luukkonen, R., & Punakallio, A. (2014). Sleep disturbances predict long-term changes in low back pain among Finnish firefighters: 13-year follow-up study. International Archives of Occupational and Environmental Health,. doi:10.1007/s00420-014-0968-z.
Maislin, G., Pack, A. I., Kribbs, N. B., Smith, P. L., Schwartz, A. R., Kline, L. R., et al. (1995). A survey screen for prediction of apnea. Sleep, 18(3), 158–166.
Matteson-Rusby, S. E., Pigeon, W. R., Gehrman, P., & Perlis, M. L. (2010). Why treat insomnia? Primary Care Companion to The Journal of Clinical Psychiatry, 12(1), PCC.08r00743. doi: 10.4088/PCC.08r00743bro.
McCracken, L. M., & Iverson, G. L. (2002). Disrupted sleep patterns and daily functioning in patients with chronic pain. Pain Research and Management, 7(2), 75–79.
McCurry, S. M., Shortreed, S. M., Von Korff, M., Balderson, B. H., Baker, L. D., Rybarczyk, B. D., et al. (2014). Who benefits from CBT for insomnia in primary care? Important patient selection and trial design lessons from longitudinal results of the Lifestyles trial. Sleep, 37(2), 299–308. doi:10.5665/sleep.3402.
Mitchell, M. D., Gehrman, P., Perlis, M., & Umscheid, C. A. (2012). Comparative effectiveness of cognitive behavioral therapy for insomnia: A systematic review. BMC Family Practice, 13, 40. doi:10.1186/1471-2296-13-40.
Morin, C. M., Belleville, G., Belanger, L., & Ivers, H. (2011). The Insomnia Severity Index: Psychometric indicators to detect insomnia cases and evaluate treatment response. Sleep, 34(5), 601–608.
Morin, C. M., LeBlanc, M., Daley, M., Gregoire, J. P., & Merette, C. (2006). Epidemiology of insomnia: Prevalence, self-help treatments, consultations, and determinants of help-seeking behaviors. Sleep Medicine, 7(2), 123–130. doi:10.1016/j.sleep.2005.08.008.
Nowell, P. D., Mazumdar, S., Buysse, D. J., Dew, M. A., Reynolds, C. F, 3rd, & Kupfer, D. J. (1997). Benzodiazepines and zolpidem for chronic insomnia: A meta-analysis of treatment efficacy. JAMA, The Journal of the American Medical Association, 278(24), 2170–2177.
Okifuji, A., & Hare, B. D. (2011). Do sleep disorders contribute to pain sensitivity? Current Rheumatology Reports, 13(6), 528–534. doi:10.1007/s11926-011-0204-8.
Perlis, M., Gehrman, P., & Riemann, D. (2008). Intermittent and long-term use of sedative hypnotics. Current Pharmaceutical Design, 14(32), 3456–3465.
Perlis, M. L., Giles, D. E., Mendelson, W. B., Bootzin, R. R., & Wyatt, J. K. (1997). Psychophysiological insomnia: The behavioural model and a neurocognitive perspective. Journal of Sleep Research, 6(3), 179–188.
Rodin, E. A., Daly, D. D., & Bickford, R. G. (1955). Effects of photic stimulation during sleep; A study of normal subjects and epileptic patients. Neurology, 5(3), 149–159.
Roth, T., Walsh, J. K., Krystal, A., Wessel, T., & Roehrs, T. A. (2005). An evaluation of the efficacy and safety of eszopiclone over 12 months in patients with chronic primary insomnia. Sleep Medicine, 6(6), 487–495. doi:10.1016/j.sleep.2005.06.004.
Schutte-Rodin, S., Broch, L., Buysse, D., Dorsey, C., & Sateia, M. (2008). Clinical guideline for the evaluation and management of chronic insomnia in adults. Journal of Clinical Sleep Medicine, 4(5), 487–504.
Smith, M. T., & Haythornthwaite, J. A. (2004). How do sleep disturbance and chronic pain inter-relate? Insights from the longitudinal and cognitive–behavioral clinical trials literature. Sleep Medicine Reviews, 8(2), 119–132.
Smith, M. T., Perlis, M. L., Park, A., Smith, M. S., Pennington, J., Giles, D. E., et al. (2002). Comparative meta-analysis of pharmacotherapy and behavior therapy for persistent insomnia. The American Journal of Psychiatry, 159(1), 5–11.
Teplan, M., Krakovska, A., & Stolc, S. (2006). EEG responses to long-term audio–visual stimulation. International Journal of Psychophysiology, 59(2), 81–90. doi:10.1016/j.ijpsycho.2005.02.005.
Teplan, M., Krakovska, A., & Stolc, S. (2011). Direct effects of audio–visual stimulation on EEG. Computer Methods and Programs in Biomedicine, 102(1), 17–24.
Turk, D. C., & Cohen, M. J. (2010). Sleep as a marker in the effective management of chronic osteoarthritis pain with opioid analgesics. Seminars in Arhritis and Rheumatism, 39(6), 477–490.
Vitiello, M. V., McCurry, S. M., Shortreed, S. M., Baker, L. D., Rybarczyk, B. D., Keefe, F. J., et al. (2014). Short-term Improvement in insomnia symptoms predicts long-term improvements in sleep, pain, and fatigue in older adults with co-morbid osteoarthritis and insomnia. Pain,. doi:10.1016/j.pain.2014.04.032.
Vitiello, M. V., Rybarczyk, B., Von Korff, M., & Stepanski, E. J. (2009). Cognitive behavioral therapy for insomnia improves sleep and decreases pain in older adults with co-morbid insomnia and osteoarthritis. Journal of Clinical Sleep Medicine, 5(4), 355–362.
Walters, A. S., LeBrocq, C., Dhar, A., Hening, W., Rosen, R., Allen, R. P., et al. (2003). Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Medicine, 4(2), 121–132.
Wang, M. Y., Wang, S. Y., & Tsai, P. S. (2005). Cognitive behavioural therapy for primary insomnia: A systematic review. Journal of Advanced Nursing, 50(5), 553–564. doi:10.1111/j.1365-2648.2005.03433.x.
Wunderlich, G. R., Evans, K. R., Sills, T., Pollentier, S., Reess, J., Allen, R. P., et al. (2005). An item response analysis of the international restless legs syndrome study group rating scale for restless legs syndrome. Sleep Medicine, 6(2), 131–139.
Acknowledgments
This project was conducted with the support of (1) John A. Hartford Foundation Claire M. Fagin Fellowship—National Hartford Center of Gerontological Nursing Excellence, (2) National Institute of Nursing Research T-32 Post-doctoral fellowship (NINR 5-T32-NR009356) from the NewCourtland Center for Transitions and Health, School of Nursing University of Pennsylvania, (3) the pilot study fund from the Biobehavioral Research Center, School of Nursing University of Pennsylvania, (4) the Sinegal Faculty Development Fund, College of Nursing, Seattle University, and (5) Center for Research on the Management of Sleep Disturbances (P30 NR011400), University of Washington. Special thanks to Akiko Miller, Yip-Han Lee, Taylor Goulding, Cara Mcguinness, and Regina Belche for their exceptional assistance and contribution on the project.
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Tang, HY., Vitiello, M.V., Perlis, M. et al. A Pilot Study of Audio–Visual Stimulation as a Self-Care Treatment for Insomnia in Adults with Insomnia and Chronic Pain. Appl Psychophysiol Biofeedback 39, 219–225 (2014). https://doi.org/10.1007/s10484-014-9263-8
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DOI: https://doi.org/10.1007/s10484-014-9263-8