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Pharmacodynamic parameters of anticoagulants based on sulfated polysaccharides from marine algae

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Abstract

Fucoidans isolated from Fucus evanescens and Laminaria cichorioides kelp can inhibit thrombin and factor Xa of the blood coagulation system. In rats, intravenous injection of fucoidans dose-dependently increased anticoagulant activity of the plasma. Fucoidans can form complexes with protamine sulfate. The observed quantitative differences in the action of fucoidans can result from different sulfation degree and the presence of various types of glycoside bonds in polysaccharide molecules.

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Authors and Affiliations

  1. Department of Pathology and Pharmacology of Hemostasis, Hematology Research Center, Russian Academy of Medical Sciences, Moscow

    N. N. Drozd, A. S. Tolstenkov & V. A. Makarov

  2. Department of Immunology, Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok

    T. A. Kuznetsova & N. N. Besednova

  3. Department of Enzyme Chemistry, Pacific Institute of Bioorganic Chemistry, Far East Division, Russian Academy of Sciences, Vladivostok

    N. M. Shevchenko & T. N. Zvyagintseva

Authors
  1. N. N. Drozd
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  2. A. S. Tolstenkov
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  3. V. A. Makarov
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  4. T. A. Kuznetsova
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  5. N. N. Besednova
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  6. N. M. Shevchenko
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  7. T. N. Zvyagintseva
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Correspondence to N. N. Drozd.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 11, pp. 537–540, November, 2006

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Drozd, N.N., Tolstenkov, A.S., Makarov, V.A. et al. Pharmacodynamic parameters of anticoagulants based on sulfated polysaccharides from marine algae. Bull Exp Biol Med 142, 591–593 (2006). https://doi.org/10.1007/s10517-006-0426-3

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  • DOI: https://doi.org/10.1007/s10517-006-0426-3

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