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Rapid Mixing Using Two-Phase Hydraulic Focusing in Microchannels

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Abstract

Rapid mixing is important in biomedical analysis. In this study, rapid mixing is obtained through two-phase hydraulic focusing in microchannels. Two mixing streams are focused by two sheath streams. Assuming a laminar flow in the channel, the spreading behavior of the two immiscible fluids is modeled and solved analytically. The results show that both viscosity ratio and flow rate ratio between the sheath flow and the sample flow can affect the focusing ratio. Thus, the mixing path of the sample flows can be adjusted by either viscosity ratio or flow rate ratio. Furthermore, an analytical model was proposed and solved for convective/diffusive mixing between the sample streams. According to this model, the focusing ratio is a key parameter for rapid mixing. A fully polymeric micro mixer was fabricated and tested for verification of the presented analytical models. The micromixer was fabricated by laser micromachining and adhesive bonding. The characterization results show the promising potential of mixing in microscale using two-phase hydraulic focusing.

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References

  • J. Branebjerg et al. in Proceedings of MEMS’96, 9th IEEE International Workshop Micro Electromechanical System (San Diego, CA, 1996), p. 441.

  • H. Chen and J.C. Meiners, Applied Physics Letters 84, 2193 (2004).

    Google Scholar 

  • D. Gobby, P. Angeli, and A. Gavriilidis, Journal of Micromechanics and Microengineering 11, 126 (2001).

    Google Scholar 

  • V. Haverkamp, W. Ehrfeld, K. Gebauer, V. Hessel, H. Lwe, T. Richter, and C. Wille, Fresenius Journal of Analytical Chemistry 364, 617 (1999).

    Google Scholar 

  • R.J. Jackman, T.M. Floyd, R. Ghodssi, M.A. Schmidt, and K.F. Jensen, Journal of Micromechanics and Microengineering 11, 263 (2001).

    Google Scholar 

  • T.J. Johnson, D. Ross and L.E. Locascio, Analytical Chemistry 74, 45 (2002).

    Google Scholar 

  • J.B. Knight, A. Vishwanath, J.P. Brody, and R.H. Austin, Physical Review Letters 80, 3863 (1998).

    Google Scholar 

  • M. Koch, H. Witt, A.G.R. Evans, and A. Brunnschweiler, Journal of Micromechanics and Microengineering 9, 156 (1999).

    Google Scholar 

  • Y. Lin, G.J. Gerfen, D.L. Rousseau, and S.R. Yeh, Analytical Chemistry 75, 5381 (2003).

    Google Scholar 

  • R.H. Liu, M.A. Stremler, K.V. Sharp, M.G. Olsen, J.G. Santiago, R.J. Adrian, H. Aref, and D.J. Beebe, Journal of Microelectromechanical Systems 9, 190 (2000).

    Google Scholar 

  • R. Miyake, T.S.J. Lammerink, M. Elwenspoek, and J.H.J. Fluitman, in Proceedings of MEMS’93, 6th IEEE International Workshop Micro Electromechanical System (San Diego, CA, 1993) p. 248.

  • Möbius et al., in Proceedings of Transducers ‘95, 8th International Conference on Solid-State Sensors and Actuators (Stockholm, Sweden, 1995), p. 775.

  • N.T. Nguyen and S.T. Wereley, Fundamentals and Applications of Microfluidics (Artech House, Boston, 2002).

    Google Scholar 

  • N. Schwesinger, T. Frank, and H. Wurmus, Journal of Micromechanics and Microengineering 6, 99 (1996).

    Google Scholar 

  • A.D. Stroock, S.K.W. Dertinger, A. Ajdari, I. Mezic, H.A. Stone, and G.M. Whitesides, Science 295, 647 (2002).

    Google Scholar 

  • J.D. Tice, H. Song, A.D. Lyon, and R.F. Ismagilov, Langmuir 19, 9127 (2003).

    Google Scholar 

  • T.T. Veenstra, Journal of Micromechanics and Microengineering 9, 199 (1999).

    Google Scholar 

  • R.A. Vijiayendran, K.M. Motsegood, D.J. Beebe, and D.E. Leckband, Langmuir 19, 1824 (2000).

    Google Scholar 

  • H. Wang, P. Iovenitti, E. Harvey, S. Masood, and Smart Materials and Structures 11, 662 (2002).

    Google Scholar 

  • S.H. Wong, M.C.L. Ward, and C.W. Wharton, Sensors and Actuators B 95, 414 (2002).

    Google Scholar 

  • Z. Wu, N.T. Nguyen, and X.Y. Huang, Journal of Micromechanics and Microengineering 14, 604 (2004).

    Google Scholar 

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Correspondence to Nam-Trung Nguyen.

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Wu, Z., Nguyen, NT. Rapid Mixing Using Two-Phase Hydraulic Focusing in Microchannels. Biomed Microdevices 7, 13–20 (2005). https://doi.org/10.1007/s10544-005-6167-7

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  • DOI: https://doi.org/10.1007/s10544-005-6167-7

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