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188Re-labeled MPEG-modified superparamagnetic nanogels: preparation and targeting application in rabbits

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Abstract

Polyacrylamide-coated magnetic nanogels were synthesized via photochemical method in surfactants and initiators free aqueous system at room temperature. After Hoffmann elimination of carbonyl and further modification with methoxy poly(ethylene glycol) (MPEG), the MPEG-modified superparamagnetic nanogels (MSN) with better hydrophilicity and biocompatibility were obtained. The MSN were characterized by FTIR, XRD, SEM and PCS. Covalently linked with 188Re complex, the 188Re-labeled MSN were prepared and intravenously injected into the left ears of the anesthetized rabbits in control group (without external magnetic field) or in targeting group (in presence of external magnetic field). The average radioactivity distribution of organs in control group was detected and the magnetic targeting feature was investigated in targeting group.

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Acknowledgments

This work is supported by Science & Technology Commission of Shanghai Municipality (No.0352nm120) and the Knowledge Innovation Project of Chinese Academy of Sciences (No.90120310).

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Authors and Affiliations

  1. Dezhou University, Dezhou, Shangdong, 253023, Peoples’ Republic of China

    Hanwen Sun, Lianying Zhang, Xiuling Zhang, Cunlan Zhang & Zhenlin Wei

  2. Radiation Research Center, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, Peoples’ Republic of China

    Hanwen Sun & Side Yao

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  1. Hanwen Sun
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  2. Lianying Zhang
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  3. Xiuling Zhang
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Correspondence to Hanwen Sun.

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Sun, H., Zhang, L., Zhang, X. et al. 188Re-labeled MPEG-modified superparamagnetic nanogels: preparation and targeting application in rabbits. Biomed Microdevices 10, 281–287 (2008). https://doi.org/10.1007/s10544-007-9134-7

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