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Nitrate Therapy in Acute Myocardial Infarction: Potion or Poison?

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References

  1. Yamauchi T, Hagiwara N, Kasanuki H, Koyanagi R, Ogawa H. Long-term nitrate use in acute myocardial infarction (The Heart Institute of Japan, Department of Cardiology Nitrate Evaluation Program). CV Drug Ther. 2008;(in press).

  2. Gori T, Parker JD. Nitrate tolerance: a unifying hypothesis. Circulation. 2002;106:2510–3.

    Article  PubMed  Google Scholar 

  3. Abrams J. Mechanisms of action of the organic nitrates in the treatment of myocardial ischemia. Am J Cardiol. 1992;70:30B–42B.

    Article  PubMed  CAS  Google Scholar 

  4. Loscalzo J. Antiplatelet and antithrombotic effects of organic nitrates. Am J Cardiol. 1992;70:18B–22B.

    Article  PubMed  CAS  Google Scholar 

  5. Heitzer T, Just H, Brockhoff C, Meinertz T, Olschewski M, Munzel T. Long-term nitroglycerin treatment is associated with supersensitivity to vasoconstrictors in men with stable coronary artery disease: prevention by concomitant treatment with captopril. J Am Coll Cardiol. 1998;31:83–8.

    Article  PubMed  CAS  Google Scholar 

  6. Chirkov YY, Horowitz JD. Impaired tissue responsiveness to organic nitrates and nitric oxide: a new therapeutic frontier? Pharmacol Ther. 2007;116:287–305.

    Article  PubMed  CAS  Google Scholar 

  7. DePace NL, Herling IM, Kotler MN, Hakki AH, Spielman SR, Segal BL. Intravenous nitroglycerin for rest angina. Potential pathophysiologic mechanisms of action. Arch Intern Med. 1982;142:1806–9.

    Article  PubMed  CAS  Google Scholar 

  8. Kaplan K, Davison R, Parker M, Przybylek J, Teagarden JR, Lesch M. Intravenous nitroglycerin for the treatment of angina at rest unresponsive to standard nitrate therapy. Am J Cardiol. 1983;51:694–8.

    Article  PubMed  CAS  Google Scholar 

  9. Roubin GS, Harris PJ, Eckhardt I, Hensley W, Kelly DT. Intravenous nitroglycerin in refractory unstable angina pectoris. Aust N Z J Med. 1982;12:598–602.

    PubMed  CAS  Google Scholar 

  10. Karlberg KE, Saldeen T, Wallin R, Henriksson P, Nyquist O, Sylven C. Intravenous nitroglycerin reduces ischaemia in unstable angina pectoris: a double-blind placebo-controlled study. J Intern Med. 1998;243:25–31.

    Article  PubMed  CAS  Google Scholar 

  11. Hackett D, Davies G, Chierchia S, Maseri A. Intermittent coronary occlusion in acute myocardial infarction. Value of combined thrombolytic and vasodilator therapy. N Engl J Med. 1987;317:1055–9.

    Article  PubMed  CAS  Google Scholar 

  12. Beltrame JF, Stewart S, Leslie S, Poropat S, Horowitz JD. Resolution of ST-segment elevation following intravenous administration of nitroglycerin and verapamil. Am J Cardiol. 2002;89:452–5.

    Article  PubMed  CAS  Google Scholar 

  13. Jugdutt B, Warnica J. Intravenous nitroglycerin therapy to limit myocardial infarct size, expansion, and complications. Effect of timing, dosage, and infarct location. Circulation. 1988;78:906–19.

    PubMed  CAS  Google Scholar 

  14. Yusuf S, Collins R, MacMahon S, Peto R. Effect of intravenous nitrates on mortality in acute myocardial infarction: an overview of the randomised trials. Lancet. 1988;1:1088–92.

    Article  PubMed  CAS  Google Scholar 

  15. ISIS-4 (Fourth International Sudy of Infarct Survival) Collaborative Group. ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. Lancet. 1995;345:669–85.

    Article  Google Scholar 

  16. Gruppo Italiano per lo Studio della Streptochinasi nell’Infarcto Miocardico (GISSI-3). GISSI-3: effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction. Lancet. 1994;343:1115–22.

    Google Scholar 

  17. ESPRIM Group. The ESPRIM trial: short-term treatment of acute myocardial infarction with molsidomine. European Study of Prevention of Infarct with Molsidomine (ESPRIM) Group. Lancet. 1994;344:91–7.

    Google Scholar 

  18. Held PH, Teo KK, Yusif S. Effects of medical therapies on acute myocardial infarction and unstable angina pectoris. In: Topol EJ, editor. Textbook of interventional cardiology. 4th ed. Oxford: Saunders; 2002. p. 65–78.

    Google Scholar 

  19. Antman EM, Anbe DT, Armstrong PW, et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction–executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the 1999 guidelines for the management of patients with acute myocardial infarction).. J Am Coll Cardiol. 2004;44:671–719.

    Article  PubMed  Google Scholar 

  20. Anderson JL, Adams CD, Antman EM, et al. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-Elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) developed in collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. J Am Coll Cardiol. 2007;50:e1–e157.

    Article  PubMed  Google Scholar 

  21. Ishikawa K, Kanamasa K, Ogawa I, et al. Long-term nitrate treatment increases cardiac events in patients with healed myocardial infarction. Secondary Prevention Group. Jpn Circ J. 1996;60:779–88.

    Article  PubMed  CAS  Google Scholar 

  22. Nakamura Y, Moss AJ, Brown MW, Kinoshita M, Kawai C. Long-term nitrate use may be deleterious in ischemic heart disease: a study using the databases from two large-scale postinfarction studies. Multicenter Myocardial Ischemia Research Group. Am Heart J. 1999;138:577–85.

    Article  PubMed  CAS  Google Scholar 

  23. Beltrame JF, Sasayama S, Maseri A. Racial heterogeneity in large vessel coronary vasomotor reactivity: differences between Japanese and Caucasian patients. J Am Coll Cardiol 1999;33:1442–52.

    Article  PubMed  CAS  Google Scholar 

  24. Pristipino C, Beltrame JF, Finocchiaro ML, et al. Major racial differences in coronary constrictor response between Japanese and Caucasians with recent myocardial infarction. Circulation. 2000;101:1102–8.

    PubMed  CAS  Google Scholar 

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Acknowledgement

Dr Beltrame is supported by a National Heart Foundation of Australia Research Fellowship and Grant-in-Aid.

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  1. The Queen Elizabeth Hospital Cardiology Unit, University of Adelaide, 28 Woodville Road, Woodville South, Adelaide, South Australia, 5011, Australia

    John F. Beltrame

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  1. John F. Beltrame
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Correspondence to John F. Beltrame.

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Beltrame, J.F. Nitrate Therapy in Acute Myocardial Infarction: Potion or Poison?. Cardiovasc Drugs Ther 22, 165–168 (2008). https://doi.org/10.1007/s10557-008-6103-1

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