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24.06.2019 | Original Research

Injectable all-polysaccharide self-assembling hydrogel: a promising scaffold for localized therapeutic proteins

verfasst von: Lei Dai, Ting Cheng, Yan Wang, Hailong Lu, Shuangxi Nie, Hong He, Chao Duan, Yonghao Ni

Erschienen in: Cellulose | Ausgabe 11/2019

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Abstract

Biomedical/pharmaceutical applications demand hydrogels made from biobased materials without the use of potentially toxic or denaturizing crosslinking agents. In this work, a new all-polysaccharide self-assembling hydrogel system consisting of anionic TEMPO-oxidized cellulose nanofibers (TOCNs) and cationic guar gum (CGG) is proposed. The TOCNs/CGG hydrogel are formed in situ when TOCNs and CGG are mixed, due to the electrostatic interactions and abundant hydrogen bondings therein. Interactions in the hydrogel were supported by Fourier transform infrared spectroscopy (FTIR) results. The as-prepared hydrogel showed good injectability, self-healing performance and reasonable mechanical properties. Scanning electron microscope (SEM) images illustrated the network structure of the hydrogel. Furthermore, the TOCNs/CGG hydrogel system was studied for protein drug release, in which bovine serum albumin (BSA) was used as a model drug to examine the drug release performance in buffers at pH 2.0 or 7.4, simulating gastrointestinal tract conditions. The results indicate its sustained drug releasing ability. A mathematical analysis of the release results supports an anomalous transport mechanism for the TOCNs/CGG hydrogel system.

Vorheriger Artikel Mg(OH)2 and PDMS-coated cotton fabrics for excellent oil/water separation and flame retardancy

Nächster Artikel Electrospinning of photo-responsive Azo-Cellulose: towards smart fibrous materials

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Titel: Injectable all-polysaccharide self-assembling hydrogel: a promising scaffold for localized therapeutic proteins
verfasst von: Lei Dai
Ting Cheng
Yan Wang
Hailong Lu
Shuangxi Nie
Hong He
Chao Duan
Yonghao Ni
Publikationsdatum: 24.06.2019
Verlag: Springer Netherlands
Erschienen in: Cellulose / Ausgabe 11/2019
Print ISSN: 0969-0239
Elektronische ISSN: 1572-882X
DOI: https://doi.org/10.1007/s10570-019-02579-7

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