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Fibroblast growth factor-2 and cardioprotection

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Abstract

Boosting myocardial resistance to acute as well as chronic ischemic damage would ameliorate the detrimental effects of numerous cardiac pathologies and reduce the probability of transition to heart failure. Experimental cardiology has pointed to ischemic and pharmacological pre- as well as post-conditioning as potent acute cardioprotective manipulations. Additional exciting experimental strategies include the induction of true regenerative and/or angiogenic responses to the damaged heart, resulting in sustained structural and functional beneficial effects. Fibroblast growth factor-2 (FGF-2), an endogenous multifunctional protein with strong affinity for the extracellular matrix and basal lamina and well-documented paracrine, autocrine and intacellular modes of action, has been shown over the years to exert acute and direct pro-survival effects, irrespectively of whether it is administered before, during or after an ischemic insult to the heart. FGF-2 is also a potent angiogenic protein and a crucial agent for the proliferation, expansion, and survival of several cell types including those with stem cell properties. Human clinical trials have pointed to a good safety record for this protein. In this review, we will present a case for the low molecular weight isoform of fibroblast growth factor-2 (lo-FGF-2) as a very promising therapeutic agent to achieve powerful acute as well as sustained benefits for the heart, due to its cytoprotective and regenerative properties.

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Acknowledgments

This work was supported (EK, PAC) by the Canadian Institutes for Health Research. ZS-J was supported by a postdoctoral award from the IMPACT-CIHR program. JJ-S and SKJ had studentship awards from the Manitoba Health Research Council and the Heart and Stroke Foundation of Canada, respectively.

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Authors and Affiliations

  1. Institute of Cardiovascular Sciences, St. Boniface Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada

    Elissavet Kardami, Xin Ma, Jon-Jon Santiago & Sarah K. Jimenez

  2. St. Boniface Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada

    Karen Detillieux & Peter A. Cattini

  3. Institute of Cardiovascular Disease, Nanhua University, Hengyang City, Hunan, P.R. China

    Zhisheng Jiang

  4. Institute of Cardiovascular Sciences, St. Boniface Research Centre, 351 Taché Avenue, Winnipeg, Manitoba, Canada, R2H 2A6

    Elissavet Kardami

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  1. Elissavet Kardami
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  2. Karen Detillieux
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  3. Xin Ma
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Correspondence to Elissavet Kardami.

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Kardami, E., Detillieux, K., Ma, X. et al. Fibroblast growth factor-2 and cardioprotection. Heart Fail Rev 12, 267–277 (2007). https://doi.org/10.1007/s10741-007-9027-0

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