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Journal of Computational Neuroscience

Erschienen in:

01.12.2009

Modelling and sensitivity analysis of the reactions involving receptor, G-protein and effector in vertebrate olfactory receptor neurons

verfasst von: Geir Halnes, Erik Ulfhielm, Emma Eklöf Ljunggren, Jeanette Hellgren Kotaleski, Jean-Pierre Rospars

Erschienen in: Journal of Computational Neuroscience | Ausgabe 3/2009

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Abstract

A biochemical model of the receptor, G-protein and effector (RGE) interactions during transduction in the cilia of vertebrate olfactory receptor neurons (ORNs) was developed and calibrated to experimental recordings of cAMP levels and the receptor current (RC). The model describes the steps from odorant binding to activation of the effector enzyme which catalyzes the conversion of ATP to cAMP, and shows how odorant stimulation is amplified and delayed by the RGE transduction cascade. A time-dependent sensitivity analysis was performed on the model. The model output—the cAMP production rate—is particularly sensitive to a few, dominant parameters. During odorant stimulation it depends mainly on the initial density of G-proteins and the catalytic constant for cAMP production.

Vorheriger Artikel Differences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents

Nächster Artikel Self-sustained asynchronous irregular states and Up–Down states in thalamic, cortical and thalamocortical networks of nonlinear integrate-and-fire neurons

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Titel: Modelling and sensitivity analysis of the reactions involving receptor, G-protein and effector in vertebrate olfactory receptor neurons
verfasst von: Geir Halnes
Erik Ulfhielm
Emma Eklöf Ljunggren
Jeanette Hellgren Kotaleski
Jean-Pierre Rospars
Publikationsdatum: 01.12.2009
Verlag: Springer US
Erschienen in: Journal of Computational Neuroscience / Ausgabe 3/2009
Print ISSN: 0929-5313
Elektronische ISSN: 1573-6873
DOI: https://doi.org/10.1007/s10827-009-0162-6

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