Abstract
Three different samples of β cyclodextrin nanosponges (CDNS) are prepared from β cyclodextrin (βCD) and pyromellitic dianhydride (PMA). CDNS are cross-linked, nanoporous materials whose pore size can be modulated by suitable choice of the CD/PMA molar ratio. In the presence of aqueous solutions they can swell giving rise to gel-like behavior. The Raman spectra of dry and water treated CDNS are described, with emphasis on the group vibration modes in the low frequency part of spectrum, sensitive to molecular environment and cross-linking degree, and on O–H/C–H vibration modes of dry/swollen CDNS, in turn providing information on the hydration dynamics. Powder X-ray diffraction data indicate low crystallinity and the presence of bulk water within the 3D polymer network. High resolution magic angle spinning (HR MAS) NMR spectroscopy is successfully used for investigation of swollen CDNS. The NMR signals of bulk and “bound” water indicate two different states of water molecules inside the gel. Probe solute fluorescein is used to spot on the diffusion properties inside the gel. In one case the diffusion coefficient of fluorescein measured in CDNS results one order of magnitude higher than that in D2O. The acceleration effect uncovered indicates that the motion of fluorescein inside the porous gel is driven by both hydrodynamic and electrostatic factors.
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Li, D., Ma, M.: New organic nanoporous polymers and their inclusion complexes. Chem. Mater. 11, 872–874 (1999)
Trotta, F., Tumiatti, W.: Patent WO 03/085002 (2003)
Trotta, F., Tumiatti, W., Cavalli, R., Zerbinati, O., Roggero, C.M., Vallero, R.: Ultrasound-assisted synthesis of cyclodextrin-based nanosponges. Patent number WO 06/002814 (2006)
Trotta, F., Cavalli, R.: Characterization and applications of new hyper-cross-linked cyclodextrins. Compos. Interface. 16, 39–48 (2009)
Cavalli, R., Trotta, F., Tumiatti, W.: Cyclodextrin-based nanosponges for drug delivery. J. Incl. Phenom. Macrocycl. Chem. 56, 209–213 (2006)
Trotta, F., Tumiatti, W., Cavalli, R., Roggero, C. M., Mognetti, B., Berta, Nicolao, G.: Cyclodextrin-based nanosponges as a vehicle for antitumoral drugs. Patent WO 09/003656 (2009)
Vyas, A., Shailendra, S., Swarnlata, S.: Cyclodextrin based novel drug delivery systems. J. Incl. Phenom. Macrocycl. Chem. 62, 23–42 (2008)
Swaminathan, S., Vavia, P.R., Trotta, F., Torne, S.: Formulation of beta-cyclodextrin based nanosponges of itraconazole. J. Incl. Phenom. Macrocycl. Chem. 57, 89–94 (2007)
Mamba, B.B., Krause, R.W., Malefetse, T.J., Gericke, G., Sithole, S.P.: Cyclodextrin nanosponges in the removal of organic matter to produce water for power generation. Water SA. 34, 657–660 (2008)
Mamba, B.B., Krause, R.W., Malefetse, T.J., Nxumalo, E.N.: Monofunctionalized cyclodextrin polymers for the removal of organic pollutants from water. Environ. Chem. Lett. 5, 79–84 (2007)
Mhlanga, S.D., Mamba, B.B., Krause, R.W., Malefetse, T.J.: Removal of organic contaminants from water using nanosponge cyclodextrin polyurethanes. J. Chem. Technol. Biot. 82, 382–388 (2007)
Arkas, M., Allabashi, R., Tsiourvas, D., Mattausch, E.-M., Perfler, R.: Organic/inorganic hybrid filters based on dendritic and cyclodextrin “nanosponges” for the removal of organic pollutants from water. Environ. Sci. Technol. 40, 2771–2777 (2006)
Trotta, F., Tumiatti, W., Vallero, R.: Italian Patent No. MI2004A000614
Huglin, M.B., Liu, Y., Velada, J.L.: Thermoreversible swelling behaviour of hydrogels based on N-isopropylacrylamide with acidic comonomers. Polymer 38, 5791–5795 (1997)
Pilla, O., Caponi, S., Fontana, A., Goncalves, J.R., Montagna, M., Rossi, F., Viliani, G., Angelani, L., Ruocco, G., Monaco, G., Sette, F.: The low energy excess of vibrational states in v-SiO2: the role of transverse dynamics. J. Phys. Condense Matter 16, 8519 (2004)
Fontana, A., Moser, E., Rossi, F., Campostrini, R., Carturan, G.: Structure and dynamics of hydrogenated silica xerogel by raman and brillouin scattering. J. Non-Cryst. Solids 212, 292 (1997)
Sekine, Y., Ikeda-Fukazawa, T.: Structural changes of water in a hydrogel during dehydration. J. Chem. Phys. 130, 034501 (2009)
Cruciani, O., Mannina, L., Sobolev, A.P., Segre, A., Luisi, P.: Multilamellar liposomes formed from phosphatidyl nucleosides: an NMR-HR MAS characterization. Langmuir 20, 1144–1151 (2004)
Violette, A., Lancelot, N., Poschalko, A., Piotto, M., Briand, J.-P., Raya, J., Bianco, A., Guichard, G.: Exploring helical folding of oligoureas during chain elongation by high-resolution magic-angle-spinning (HRMAS) NMR spectroscopy. Chem. Eur. J. 14, 3874–3882 (2008)
Mullen, M.K., Johnstone, K.D., Webb, M., Bampos, N., Sanders, J.K.M., Gunter, M.J.: Monitoring the thermodynamically controlled formation of diimide-based resin-attached rotaxanes by gel-phase HR MAS 1H NMR spectroscopy. Org. Biomol. Chem. 6, 278–286 (2008)
Schenetti, L., Mucci, A., Parenti, F., Cagnoli, R., Righi, V., Tosi, R.M., Tugnoli, V.: HR-MAS NMR spectroscopy of the human tissues: application to healthy gastric mucosa. Concept Magn. Reson A 28, 430–443 (2006)
Holz, M., Heil, S.R., Sacco, A.: Temperature-dependent self-diffusion coefficients of water and six selected molecular liquids for calibration in accurate 1H NMR PFG measurements. Phys. Chem. Chem. Phys. 2, 4740–4742 (2000)
Raffaini, G., Ganazzoli, F.: Hydration and flexibility of α-, β-, γ- and δ-cyclodextrin: a molecular dynamics study. Chem. Phys. 333, 128–134 (2007)
Perale, G., Rossi, F., Santoro, M., Marchetti, P., Mele, A., Castiglione, F., Raffa, E., Masi, M.: Drug release from hydrogels: a new understanding of transport phenomena (in press)
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Politecnico di Milano thanks Fondazione Cariplo (project 2007-5378) for financial support. This work was partially supported by the contribution from Provincia Autonoma di Trento (Italy).
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Mele, A., Castiglione, F., Malpezzi, L. et al. HR MAS NMR, powder XRD and Raman spectroscopy study of inclusion phenomena in βCD nanosponges. J Incl Phenom Macrocycl Chem 69, 403–409 (2011). https://doi.org/10.1007/s10847-010-9772-x
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DOI: https://doi.org/10.1007/s10847-010-9772-x