Skip to main content

Advertisement

SpringerLink
Log in

3D printing of hydroxyapatite scaffolds with good mechanical and biocompatible properties by digital light processing

  • Biomaterials
  • Published:
Journal of Materials Science Aims and scope Submit manuscript

Abstract

Hydroxyapatite is a scaffold material widely used in clinical repair of bone defects, but it is difficult for traditional methods to make customized artificial bone implants with complicated shapes. 3D printing biomaterials used as personalized tissue substitutes have the ability to promote and enhance regeneration in areas of defected tissue. The present study aimed at demonstrating the capacity of one 3D printing technique, digital light processing (DLP), to produce HA scaffold. Using HA powder and photopolymer as raw materials, a mixture of HA mass ratio of 30 wt% was prepared by viscosity test. It was used for forming ceramic sample by DLP technology. According to differential scanning calorimetry and thermal gravity analysis, it was revealed that the main temperature range for the decomposition of photopolymer was from 300 to 500 °C. Thus, the two-step sintering process parameters were determined, including sintering temperature range and heating rate. XRD analysis showed that the phase of HA did not change after sintering. SEM results showed that the grain of the sintered ceramic was compact. The compression model was designed by finite element analysis. The mechanical test results showed that the sample had good compression performance. The biological properties of the scaffold were determined by cell culture in vitro. According to the proliferation of cells, it was concluded that the HA scaffold was biocompatible and suitable for cell growth and proliferation. The experimental results show that the DLP technology can be used to form the ceramic scaffold, and the photopolymer in the as-printed sample can be removed by proper high-temperature sintering. The ceramic parts with good compression performance and biocompatibility could be obtained.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Figure 7
Figure 8
Figure 9

Similar content being viewed by others

References

  1. Farag MM et al (2014) Effect of gelatin addition on fabrication of magnesium phosphate-based scaffolds prepared by additive manufacturing system. Mater Lett 132:111–115

    Article  CAS  Google Scholar 

  2. Rodriguez G et al (2013) Influence of hydroxyapatite on extruded 3D scaffolds. Procedia Eng 59:263–269

    Article  CAS  Google Scholar 

  3. Zein I et al (2002) Fabrication of 3D chitosan–hydroxyapatite scaffolds using a robotic dispensing system. Biomaterials 23:1169–1185

    Article  CAS  Google Scholar 

  4. Roh HS et al (2017) Addition of MgO nanoparticles and plasma surface treatment of three-dimensional printed polycaprolactone/hydroxyapatite scaffolds for improving bone regeneration. Mater Sci Eng C-Mater 74:525–535

    Article  CAS  Google Scholar 

  5. Wu HD et al (2016) Effect of the particle size and the debinding process on the density of alumina ceramics fabricated by 3D printing based on stereolithography. Ceram Int 42:17290–17294

    Article  CAS  Google Scholar 

  6. Slots C (2017) Andersendental, Simple additive manufacturing of an osteoconductive ceramic using suspension melt extrusion. Dent Mater 33:198–208

    Article  CAS  Google Scholar 

  7. Bendtsen ST et al (2017) Development of a novel alginate-polyvinyl alcohol-hydroxyapatite hydrogel for 3D bioprinting bone tissue engineered scaffolds. J Biomed Mater Res Part A 105:1457–1468

    Article  CAS  Google Scholar 

  8. Jakus AE et al (2017) Multi and mixed 3D-printing of graphene-hydroxyapatite hybrid materials for complex tissue engineering. J Biomed Mater Res Part A 105:274–283

    Article  CAS  Google Scholar 

  9. Lee JS et al (2016) Development and analysis of three-dimensional (3D) printed biomimetic ceramic. Int J Precis Eng Manuf 17:1711–1719

    Article  Google Scholar 

  10. Li X et al (2017) Biocompatibility and physicochemical characteristics of poly(ε-caprolactone)/poly(lactide-co-glycolide)/nano-hydroxyapatite composite scaffolds for bone tissue engineering. Mater Design 114:149–160

    Article  CAS  Google Scholar 

  11. Tian X et al (2009) Process parameters analysis of direct laser sintering and post treatment of porcelain components using Taguchi’s method. J Eur Ceram Soc 29:1903–1915

    Article  CAS  Google Scholar 

  12. Muehler T et al (2015) Slurry-based additive manufacturing of ceramics. Int J Appl Ceram Technol 12:18–25

    Article  CAS  Google Scholar 

  13. Yen HC (2015) Experimental studying on development of slurry-layer casting system for additive manufacturing of ceramics. Int J Adv Manuf Technol 77:915–925

    Article  Google Scholar 

  14. Tang HH et al (2015) Slurry-based additive manufacturing of ceramic parts by selective laser burn-out. J Eur Ceram Soc 35:981–987

    Article  CAS  Google Scholar 

  15. Abdullah AM et al (2017) Mechanical and physical properties of highly ZrO2/β-TCP filled polyamide 12 prepared via fused deposition modelling (FDM) 3D printer for potential craniofacial reconstruction application. Mater Lett 189:307–309

    Article  CAS  Google Scholar 

  16. Castro J et al (2017) Fabrication, modeling, and application of ceramic-thermoplastic composites for fused deposition modeling of microwave components. IEEE Trans Microw Theory 65:2073–2084

    Article  Google Scholar 

  17. Zocca A et al (2015) Additive manufacturing of ceramics: issues, potentialities, and opportunities. J Am Ceram Soc 98:1983–2001

    Article  CAS  Google Scholar 

  18. Schwentenwein M et al (2015) Additive manufacturing of dense alumina ceramics. Int J Appl Ceram Technol 12:1–7

    Article  CAS  Google Scholar 

  19. Zanchetta ZE et al (2016) Stereolithography of SiOC ceramic microcomponents. Adv Mater 28:370–376

    Article  CAS  Google Scholar 

  20. Woodward DI et al (2015) Additively-manufactured piezoelectric devices. Phys Status Solidi A 212:2107–2113

    Article  CAS  Google Scholar 

  21. Song X et al (2015) Ceramic fabrication using mask-image-projection-based stereolithography integrated with tape-casting. J Manuf Process 20:456–464

    Article  Google Scholar 

  22. Zhou M et al (2016) Preparation of a defect-free alumina cutting tool via additive manufacturing based on stereolithography–Optimization of the drying and debinding processes. Ceram Int 42:11598–11602

    Article  CAS  Google Scholar 

  23. Celine AM et al (2016) Adding biomolecular recognition capability to 3D printed objects. Anal Chem 88:10767–10772

    Article  Google Scholar 

  24. Shao HF et al (2017) Bone regeneration in 3D printing bioactive ceramic scaffolds with improved tissue/material interface pore architecture in thin-wall bone defect. Biofabrication 9:025003

    Article  Google Scholar 

  25. Zhu W et al (2016) 3D printing of functional biomaterials for tissue engineering. Curr Opin Biotech 40:103–112

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by the Beijing Municipal Science and Technology Project (D151100001615002).

Author information

Authors and Affiliations

  1. Institute of Laser Engineering, Beijing University of Technology, Beijing, 100124, China

    Yong Zeng, Yinzhou Yan, Chunchun Liu, Peiran Li & Jimin Chen

  2. Beijing Engineering Research Center of 3D Printing for Digital Medical Health, Beijing University of Technology, Beijing, 100124, China

    Yong Zeng, Hengfeng Yan, Chunchun Liu, Peiran Li, Peng Dong & Jimin Chen

  3. College of Applied Sciences, Beijing University of Technology, Beijing, 100124, China

    Hengfeng Yan

  4. Capital Aerospace Machinery Company, Beijing, 100076, China

    Peng Dong & Ying Zhao

Authors
  1. Yong Zeng
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yinzhou Yan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hengfeng Yan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Chunchun Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Peiran Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Peng Dong
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Ying Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jimin Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jimin Chen.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zeng, Y., Yan, Y., Yan, H. et al. 3D printing of hydroxyapatite scaffolds with good mechanical and biocompatible properties by digital light processing. J Mater Sci 53, 6291–6301 (2018). https://doi.org/10.1007/s10853-018-1992-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10853-018-1992-2

Search

Navigation