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Erschienen in: Journal of Materials Science 15/2018

25.04.2018 | Biomaterials

Electrospun sandwich configuration nanofibers as transparent membranes for skin care drug delivery systems

verfasst von: Ke Ma, Yiping Qiu, Yaqin Fu, Qing-Qing Ni

Erschienen in: Journal of Materials Science | Ausgabe 15/2018

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Abstract

The development of biocompatible nanocomposites for biomedical applications such as drug release has attracted increasing attention in recent years. In this work, electrospun membranes composed of polycaprolactone (PCL) and shellac were fabricated because PCL has favorable mechanical and biological properties, such as high biocompatibility and biodegradability. Meanwhile, shellac is biocompatible and non-toxic; as a result, the fabricated membranes are attractive for controlled drug delivery. Here, PCL/shellac/PCL nanofiber membranes were treated by ethanol vapor to improve their properties for use in drug delivery applications. Salicylic acid was loaded in the drug delivery system as a model drug, and three PCL/shellac/PCL membrane configurations were investigated. Ethanol vapor treatment increased the tensile strength, flexibility, and transparency of the membranes. Both the tensile strength and drug release properties of the membranes strongly depended on the ratio of PCL to shellac.

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Metadaten
Titel
Electrospun sandwich configuration nanofibers as transparent membranes for skin care drug delivery systems
verfasst von
Ke Ma
Yiping Qiu
Yaqin Fu
Qing-Qing Ni
Publikationsdatum
25.04.2018
Verlag
Springer US
Erschienen in
Journal of Materials Science / Ausgabe 15/2018
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-018-2241-4

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