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Erschienen in: Journal of Materials Science 2/2020

01.10.2019 | Polymers & biopolymers

The preparation and property of photo- and thermo-responsive hydrogels with a blending system

verfasst von: Shirong Shuai, Siyao Zhou, Yu Liu, Weirong Huo, Hongyu Zhu, Yang Li, Zikun Rao, Cong Zhao, Jianyuan Hao

Erschienen in: Journal of Materials Science | Ausgabe 2/2020

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Abstract

Hydrogels are the attractive biomaterials for biomedical applications. The dual-stimuli-responsive system, which is sensitive to both temperature and UV irradiation, was achieved through the self-assembly of amphiphilic block copolymers in aqueous solution and the cleavage of ο-nitrobenzyl (NB) ester groups under UV irradiation. The copolymer of poly(ε-caprolactone)-b-ο-nitrobenzyl-poly(ethylene glycol)-ο-nitrobenzyl-b-poly(ε-caprolactone) (PCL-NB-PEG-NB-PCL) was prepared by ring-opening polymerization (ROP) and nucleophilic substitution reaction of ε-caprolactone (ε-CL) using photo-sensitized polyethylene glycol as an initiator. After blending with poly(ε-caprolactone)-b-poly(ethylene glycol)-b-poly(ε-caprolactone) (PCL-PEG-PCL), the system exhibited the promising dual sensitivity with wide gel-phase window and controllable sensitive properties. The structures and dual-responsive behaviors were characterized by 1H-NMR, GPC, DMA, UV–Vis, DLS and SEM. The results demonstrated the temperature and photo-sensitivity of the synthesized hydrogel and indicated that the blending of these two copolymers can easily adjust the phase transition temperature and broaden the gel-phase window through the content of NB groups in PCL-NB-PEG-NB-PCL and the hydrophilic/hydrophobic balance of system.

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Metadaten
Titel
The preparation and property of photo- and thermo-responsive hydrogels with a blending system
verfasst von
Shirong Shuai
Siyao Zhou
Yu Liu
Weirong Huo
Hongyu Zhu
Yang Li
Zikun Rao
Cong Zhao
Jianyuan Hao
Publikationsdatum
01.10.2019
Verlag
Springer US
Erschienen in
Journal of Materials Science / Ausgabe 2/2020
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-019-04010-9

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