Abstract
In the present study, silica-calcium phosphate composites (SiO2-CaP composites) were developed by mixing the starting materials (SiO2 and CaHPO4) in different ratios with the addition of 0.1% w/v NaOH solution. The phase composition of the SiO2-CaP composites was determined by XRD and FTIR. After thermal treatment at 350 ^C/1 h and at 1000 ^C/3.5 h; all SiO2-CaP composites composed of β-quartz, α-cristobalite and β-Ca2P2O7. The presence of calcium phosphate enhanced the transformation of β-quartz into α-cristobalite at 1000 ^C. SEM observation indicated favorable attachment and spreading of neonatal rat calvaria osteoblasts onto the surface of silica-rich SiO2-CaP composites. After attachment, these cells produced significantly higher amount of protein and expressed higher AP activity than cells attached to silica-poor samples. Results of the study suggested that the silica-based composites are more bioactive than calcium phosphate-based composites. Silica promoted the expression of osteoblast phenotype by both solution-mediated effect and direct interaction with the surface of the substrate.
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Ning, C.Q., Mehta, J. & El-Ghannam, A. Effects of silica on the bioactivity of calcium phosphate composites in vitro. J Mater Sci: Mater Med 16, 355–360 (2005). https://doi.org/10.1007/s10856-005-0635-8
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DOI: https://doi.org/10.1007/s10856-005-0635-8