Abstract
Chitosan-based hydrogel films having both temperature and pH sensitivity were prepared by blending chitosan with temperature sensitive poly (N-isopropylacrylamide) (PNIPAAm) and polyethylene glycol (PEG, Mw 2000). PEG was added to enhance film properties, such as thermal, mechanical and swelling properties. Differential scanning calorimetry (DSC) study indicated that the physically blended films exhibited a lower critical solution temperature (LCST) identical to that of pure PNIPAAm (around 32 °C). FT-IR data indicated that the temperature sensitivity is due to the PNIPAAm component in the film. The thermal analysis showed that chitosan and PNIPAAm were compatible and the blended films are apt to crystallize. The X-ray diffraction study further showed that the blended films had a higher crystallinity level than chitosan or PNIPAAm alone. The newly formed crystalline domains acted as physical crosslinkers and greatly increased the crosslinking level of the blended films, which, in turn, affected the swelling behavior and mechanical property of the blended films. Scanning electron microscopy (SEM) revealed that the blended swollen films exhibited a more porous structure at 37 °C (>LCST) than at room temperature (<LCST), though their swelling ratios were reduced as temperature increased from room temperature to 37 °C because of the dehydration nature of PNIPAAm at temperatures above its LCST. The results demonstrated that physically blended temperature sensitive films could be formulated, which are capable of producing more pores upon heating. The blended films were also found to be pH sensitive due to the fact that chitosan, one of the film components, has many pendant amino groups.
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B. D. RATNER and A. S. HOFFMAN, “ACS Symposium Series 31” (Washington, DC: American Chemical Society, 1976), pp. 1–36
K. PARK and H. PARK, In “Concise Polymeric Materials Encyclopedia,” edited by J. C. Salamone (Boca Raton: CRC Press, 1999), pp. 1476–1478
A. S. HOFFMAN, J. Control. Rel. 6 (1987) 297
N. A. PEPPAS and J. KLIER, J. Control. Rel. 16 (1991) 203
G. H. CHEN and A. S. HOFFMAN, Nature 373 (1995)49
Z. S. LIU and P. CALVERT, Adv. Mater. 12 (2000) 288
S. J. KIM, S. G. YOON, Y. M. LEE and S. I. KIM, Sensors Actuators B: Chem. 88 (2003) 286
A. MANADA, T. TANAKA, D. KUNGWATCHAKUN and M. IRIE, Macromolecules 23 (1999) 1517
L.E. BROMBERG and E. S. RON, Adv. Drug Deliver. Rev. 31 (1998) 197
X. Z. ZHANG, Y. Y. YANG, T. S. CHUNG and K. X. MA, Langmuir 17 (2001) 6094
R. A. STILE, W. R. BURGHARDT and K. E. HEALY, Macromolecules 32 (1999) 7370
X. Z. ZHANG, Y. Y. YANG and T. S. CHUNG, Langmuir 18 (2002) 2538
M. KURISAWA, M. YOKOYAMA and T. OKANO, J. Control. Rel. 69 (2000) 127
S. K. LI and A. D’EMANUELE, J. Control. Rel. 75 (2001) 55
R. YOSHIDA, K. UCHIDA, Y. KANEKO, K. SAKAI, A. KIKUCHI, Y. SAKURAI and T. OKANO, Nature 374 (1995) 240
Y. QIO and K. PARK, Adv. Drug Deliver. Rev. 53 (2001) 321
H. ICHIKAWA and Y. FUKUMORI, J. Control. Rel. 63 (2000) 107
X. Z. ZHANG, R. X. ZHUO, J. Z. CUI and J. T. ZHANG, Int. J. Pharm. 235 (2002) 43
G. CHEN and A. C. HOFFMAN, Nature 373 (1995) 49
W. E. HENNINK and C. F. van NOSTRUM, Adv. Drug Delver. Rev. 54 (2002) 13
Y. IKADA, K. JAMSHIDI, H. TSUJI and S. H. HYON, Macromolecules, 20 (1987) 904
K. NAKAMAE, T. MIYATA and A. S. HOFFMAN, J. Biomater. Sci. Polym. Ed. 6 (1994) 79
T. INOUE, G. H. CHEN, A. S. HOFFMAN and K. NAKAMAE, J. Bioact. Compat. Pol. 13 (1998) 50
B. JEONG, S. W. KIM and Y. H. BAE, Adv. Drug Delver. Rev. 54 (2002) 37
K. KAMATH and K. PARK, Adv. Drug Delver. Rev. 11 (1993) 59
D. CAMPOCCIA, P. DOHERTY, M. RADICE, P. BURN, G. ABATANGELO and D. F. WILLIAMS, Biomaterials 19 (1998) 2101
G. D. PRESTWICH, D. M. MARECAK, J. F. MARECAK, K. P. VERCRUYSSE and M. R. ZIEBELL, J. Control. Rel. 53 (1998) 93
D. K. SINGH and A. R. RAY, J. Macromol. Sci. R. M. C.C 40 (2000) 69
V. DODANE and V. D. VILIVALAM, Pharm. Sci. Technol. To. 1 (1998) 246
M. ZHANG, X. H. LI, Y. D. DONG, N. M. ZHAO and X. F. ZHANG, Biomaterials 23 (2002) 2641
X. Z. ZHANG and C. C. CHU, J. Appl. Polym. Sci. 89 (2003) 1935
S. J. LEE, S. S. KIM and Y. M. LEE, Carbohydr. Polym. 41 (2000) 197
J. H. KIM and Y. M. LEE, Polymer 34 (1993) 1952
S. Y. KIM, S. M. CHO, Y. M. LEE and S. J. KIM, J. Appl. Polym. Sci. 78 (2000) 1381
G. W. URBANCZYK and B. LIPPSYMONOWICZ, J. Appl. Polym. Sci. 51 (1994) 2191
J. LI, J. F. REVOL and R. H. MARCHESSAULT, J. Appl. Polym. Sci. 65 (1997) 373
K. V. H. PRASHANTH, F. S. KITTUR and R. N. THARANATHAN, Carbohydr. Polym. 50 (2002) 27
F. L. MI, H. W. SUNG, S. S. SHYU, C. C. SU and C. K. PENG, Polymer 44 (2003) 6251
W. ZHAO, L. YU, X. ZHONG, Y. ZHANG and J. SUN, J. Macromol. Sci. Phys. B34 (1995) 231
A. A. S. MACHADO, V. C. A. MARTINS and A. M. G. PLPIS, J. Therm. Anal. Calorim. 67 (2002) 491
S. Y. NAM and Y. M. LEE, J. Membr. Sci. 135 (1997) 161
J. S. AHN, H. K. CHOI and C. S. CHO, Biomaterials 22 (2001) 923
K. SAKURAI, T. MAEGAWA and T. TAKAHASHI, Polymer 41 (2000) 7051
A. K. BAJPAI and M. SHRIVASTAVA, J. Biomater. Sci. Polym. Edu. 13 (2002) 237
I. M. WIENK, R. M. BOOM, M. A. M. BEERLAGE, A. M. W. BULTE, C. A. SMOLDERS and H. STRATHMANN, J. Membr. Sci. 113 (1996) 361
T. BUDTOVA, N. BELNIKEVICH, L. KALYUZHNAYA, V. ALEXEEV, S. BRONNIKOV, S. VESNEBOLOTSKAYA and Z. ZOOLSHOEV, J. Appl. Polym. Sci. 84 (2002) 1114
M. T. GARAY, M. C. LLAMAS and E. IGLESIAS, Polymer 38 (1997) 5091
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Sun, G., Zhang, XZ. & Chu, CC. Formulation and characterization of chitosan-based hydrogel films having both temperature and pH sensitivity. J Mater Sci: Mater Med 18, 1563–1577 (2007). https://doi.org/10.1007/s10856-007-3030-9
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DOI: https://doi.org/10.1007/s10856-007-3030-9