Skip to main content

Advertisement

SpringerLink
Log in

In vivo behavior of bioactive phosphate glass-ceramics from the system P2O5–Na2O–CaO containing TiO2

  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

Soda lime phosphate bioglass-ceramics with incorporation of small additions of TiO2 were prepared in the metaphosphate and pyrophosphate region, using an appropriate two-step heat treatment of controlled crystallization defined by differential thermal analysis results. Identification and quantification of crystalline phases precipitated from the soda lime phosphate glasses were performed using X-ray diffraction analysis. Calcium pyrophosphate (β-Ca2P2O7), sodium metaphosphate (NaPO3), calcium metaphosphate (β-Ca(PO3)2), sodium pyrophosphate (Na4P2O7), sodium calcium phosphate (Na4Ca(PO3)6) and sodium titanium phosphate (Na5Ti(PO4)3) phases were detected in the prepared glass-ceramics. The degradation of the prepared glass-ceramics were carried out for different periods of time in simulated body fluid at 37 °C using granules in the range of (0.300–0.600 mm). The released ions were estimated by atomic absorption spectroscopy and the surface textures were measured by scanning electron microscopy. Evaluation of in vivo bioactivity of the prepared glass-ceramics was carried through implanting the samples in the rabbit femurs. The results showed that the addition of 0.5 TiO2 mol% enhanced the bioactivity while further increase of the TiO2 content decreased the bioactivity. The effect of titanium dioxide on the bioactivity was interpreted on the basis of its action on the crystallization process of the glass-ceramics.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12
Fig. 13
Fig. 14
Fig. 15

Similar content being viewed by others

References

  1. L. L. HENCH, J. Am. Ceram. Soc. 81 (1998) 1705

    Article  CAS  Google Scholar 

  2. J. C. KNOWLES and G. W. HASTINGS, J. Mater. Sci. Mater. Med. 4 (1993) 102

    Article  CAS  Google Scholar 

  3. P. Y. SHIH, S. W. YUNG and T. S. CHIN, J. Non-Cryst. Solids 224 (1998) 143

    Article  CAS  Google Scholar 

  4. X. J. XU, D. E. DAY, R. K. BROW and P. M. CALLAHAN, Phys. Chem. Glasses 36 (1995) 264

    CAS  Google Scholar 

  5. B. C. SALES, R. S. RAMSEY, J. B. BATES and L. A. BOATNER, J. Non-Cryst. Solids 87 (1986) 137

    Article  CAS  Google Scholar 

  6. K. FRANKS, I. ABRAHAMS, G. GEORGIOU and J. C. KNOWLES, Biomaterials 22 (2001) 497

    Article  CAS  Google Scholar 

  7. V. SALIH, K. FRANKS, M. JAMES, J. M. HASTINGS, J. C. KNOWLES and J. OLSEN, J. Mater. Sci. Mater. Med. 11 (2000) 615

    Article  CAS  Google Scholar 

  8. P. W. MCMILLAN, Glass-ceramics, 2nd edn (Academic Press: London, 1979)

    Google Scholar 

  9. W. VOGEL, Glass chemistry (Springer: Berlin, 1994)

    Google Scholar 

  10. Y. NAN, W. E. LEE and P. F. JAMES, J. Am. Ceram. Soc. 75 (1992) 1641

    Article  CAS  Google Scholar 

  11. P. F. JAMES, J. Non-Cryst. Solids 181 (1995) 1

    Article  CAS  Google Scholar 

  12. H. HOSONO, Z. ZHANG and Y. ABE, J. Am. Ceram. Soc. 72 (1989) 1587

    Article  CAS  Google Scholar 

  13. H. HOSONO and Y. ABE, J. Non-Cryst. Solids 190 (1995) 185

    Article  CAS  Google Scholar 

  14. S. R. LACERDA, J. M. OLIVEIRA, R. N. CORREIA and M. H. V. FERNANDES, J. Non-Cryst. Solids 221 (1997) 255

    Article  CAS  Google Scholar 

  15. T. KASUGA, M. SAWADA, M. NOGAMI and Y. ABE, Biomaterials 20 (1999) 1415

    Article  CAS  Google Scholar 

  16. T. KASUGA, Y. HOSOI, M. NOGAMI and M. NIINOMI, J. Am. Ceram. Soc. 84 (2001) 450

    Article  CAS  Google Scholar 

  17. H. GRUSSAUTE, L. MONTAGNE, G. PALAVIT and J. L. BERNARD, J. Non-Cryst. Solids 263&264 (2000) 312

    Article  CAS  Google Scholar 

  18. M. NAVARRO, M.-P. GINEBRA, J. CLEMENT, M. SALVADOR, A. GLORIA and J. A. PLANELL, J. Am. Ceram. Soc. 86 (2003) 1345

    Article  CAS  Google Scholar 

  19. S. LANGSTAFF, M. SAYER, T. J. N. SMITH, S. M. PUGH, S. A. M. HESP and W. T. THOMPSON, Biomaterials 20 (1999) 1727

    Article  CAS  Google Scholar 

  20. S. KOTANI, Y. FUJITA, T. KITSUGI, T. NAKAMURA, T. YAMAMURO, C. OHTSUKI and T. KOKUBO, J. Biomed. Mater. Res. 25 (1991) 1303

    Article  CAS  Google Scholar 

  21. M. NEO, S. KOTANI, Y. FUJITA, T. NAKAMURA, T. YAMAMURO, Y. BANDO, C. OHTSUKI and T. KOKUBO, J. Biomed. Mater. Res. 26 (1992) 255

    Article  CAS  Google Scholar 

  22. T. KOKUBO, H. KUSHITANI, S. SAKKA, T. KITSUGI and T. YAMAMURO, J. Biomed. Mater. Res. 24 (1990) 721

    Article  CAS  Google Scholar 

  23. R. K. BROW, D. R. TALLANT, W. L. WARREN, A. MCINTYRE and D. E. DAY, Phys. Chem. Glasses 38 (1997) 300

    CAS  Google Scholar 

  24. L. KOUDELKA, P. MOSNER, M. ZEYER and C. JAGER, J. Non-Cryst. Solids 326&327 (2003) 72

    Article  CAS  Google Scholar 

  25. A. SHAIM, M. ET-TABIROU, L. MONTAGNE and G. PALAVIT, Mater. Res. Bull. 37 (2002) 2459

    Article  CAS  Google Scholar 

  26. W. VOGEL and W. HOLAND, Angew. Chem. Int. Ed. Engl. 26 (1987) 527

    Article  Google Scholar 

  27. J. ALKEMPER and H. FUESS, J. Non-Cryst. Solids 210 (1997) 32

    Article  CAS  Google Scholar 

  28. I. ABRAHAMS, G. E. HAWKES and J. C. KNOWLES, J. Chem. Soc. Dalton Trans. (1997) 1483

  29. Y. ZHANG and J. D. SANTOS, J. Non-Cryst. Solids 272 (2000) 14

    Article  CAS  Google Scholar 

  30. P. HARTMANN, J. VOGEL and B. SCHNABEL, J. Non-Cryst. Solids 176 (1994) 157

    Article  CAS  Google Scholar 

  31. B. C. BUNKER, G. W. ARNOLD and J. A. WILDER, J. Non-Cryst. Solids 64 (1984) 291

    Article  CAS  Google Scholar 

  32. H. GAO, T. TAN and D. WANG, J. Control. Release 96 (2004) 29

    Article  CAS  Google Scholar 

  33. F.-H. LIN, C.-J. LIAO, K. S. CHEN, J.-S. SUN and H.-C. LIU, Biomaterials 18 (1997) 915

    Article  CAS  Google Scholar 

  34. J. M. ANTONUCCI, B. O. FOWLER and S. VENZ, Dent. Mater. 7 (1991) 124

    Article  CAS  Google Scholar 

  35. D. R. LIDE, CRC handbook of physics and chemistry (CRC Press: Boca Raton, 2004)

  36. T. KITSUGI, T. YAMAMURO, T. NAKAMURA and M. OKA, Biomaterials 16 (1995) 1101

    Article  CAS  Google Scholar 

  37. T. KITSUGI, T. YAMAMURO, T. NAKAMURA, S. KOTANI, T. KOKUBO and H. TAKEUCHI, Biomaterials 14 (1993) 216

    Article  CAS  Google Scholar 

Download references

Acknowledgement

We would like to express our gratitude to Dr. A. Elkady for her generous help.

Author information

Authors and Affiliations

  1. Biophysics Department, Faculty of Science, Cairo University, Cairo, Egypt

    Ahmed Soltan Monem

  2. Glass Research Department, National Research Center, Dokki, Cairo, Egypt

    Hatem A. ElBatal & Moenis A. Azooz

  3. Spectroscopy Department, National Research Center, Dokki, Cairo, Egypt

    Elsayed M. A. Khalil & Yousry M. Hamdy

Authors
  1. Ahmed Soltan Monem
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hatem A. ElBatal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Elsayed M. A. Khalil
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Moenis A. Azooz
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yousry M. Hamdy
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yousry M. Hamdy.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Monem, A.S., ElBatal, H.A., Khalil, E.M.A. et al. In vivo behavior of bioactive phosphate glass-ceramics from the system P2O5–Na2O–CaO containing TiO2 . J Mater Sci: Mater Med 19, 1097–1108 (2008). https://doi.org/10.1007/s10856-007-3044-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10856-007-3044-3

Keywords

Search

Navigation