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Preparation and properties of a novel bone repair composite: nano-hydroxyapatite/chitosan/carboxymethyl cellulose

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Abstract

Nano-hydroxyapatite/chitosan/carboxymethyl cellulose (n-HA/CS/CMC) composites with weight ratios of 70/10/20, 70/15/15 and 70/20/10 were prepared through a co-solution method. The properties of the composites were characterized by means of burn-out test, IR, XRD, TEM and universal material testing machine. The degradation and bioactivity were also investigated by in vitro test in a simulated body fluid (SBF) for 8 weeks. The results showed that n-HA particles were dispersed uniformly in organic phase, and strong chemical interactions formed among the three phases. Moreover, the composites were similar to natural bone in morphology and size. In addition, the compressive strength was improved compared with n-HA/CS composite. The biodegradation rate was controllable by altering weight ratio of the CS/CMC. Meanwhile, the composites could induce apatite particles to deposit in SBF. All the above results indicate that the novel composites of n-HA/CS/CMC have a promising prospect used for bone repair materials in view of the good mechanical property, adjustable biodegradation rate and bioactivity in SBF. Additionally, the study would provide a good guide to exploit clinical application of natural cellulose.

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References

  1. D. R. BISWAL and R. P. SINGH, Carbohydr. Polym. 57 (2004) 379

    Article  CAS  Google Scholar 

  2. C. H. N. SIEGER, A. G. M. KROON, J. G. BATELAAN and C. G. Van GINKEL, Carbohydr. Polym. 27 (1995) 137

    Article  CAS  Google Scholar 

  3. E. K. JUST and T. G. MAJEWICZ, Encyclopedia of Polymer Science and Technology, 2nd Ed., Vol. 3, Wiley, New York, 1989, pp 226

  4. D. L. HE, L. L. BAO, Y. M. LONG, W. Z. WEI and S. Z. YAO, Talanta 50 (2000) 1267

    Article  CAS  Google Scholar 

  5. J. W. BURNS, M. J. COLT, L. S. BURGESS and K. C. SKINNER, Eur. J. Surg. 577 (Suppl) (1997) 40

    Google Scholar 

  6. D. E. BECK, Eur. J. Surg. 577 (Suppl) (1997) 49

    Google Scholar 

  7. K. KURASHINA, H. KURITA, H. TAKEUCHI, M. HIRANO, C. KLEIN and K. De GROOT, Biomaterials 16 (1995) 119

  8. W. SUCHANEK and M. YOSHIMURA, J. Mater. Res. 13 (1998) 94

    Article  CAS  Google Scholar 

  9. T. J. WEBSTER, R. W. SIEGEL and R. BIZIOS, Biomaterials 21 (2000) 1803

    Article  CAS  Google Scholar 

  10. L. G. GUTWEIN and T. J. WEBSTER, Biomaterials 18 (2004) 4175

    Article  CAS  Google Scholar 

  11. W. TAN, R. KRISHNARAJ and T. A. DESAI, Tissue Eng. 2 (2001) 203

    Article  Google Scholar 

  12. S. ITOH, M. KIKUCHI, K. TAKAKUDA, Y. KOYAMA, H. N. MATSUMOTO, S. ICHINOSE, J. TANAKA, T. KAWAUCHI and K. SHINOMIYA, J. Biomed. Mater. Res. Part A 54 (2001) 445

    Article  CAS  Google Scholar 

  13. Y. WATANABLE, H. ERYU and K. MATSUURA, Acta Mater. 5 (2001) 775

    Article  Google Scholar 

  14. Z. K. HONG, X. Y. QIU, S. JINGRU, M. X. DENG, X. S. CHEN and X. B. JING, Polymer 45 (2004) 6699

    Article  CAS  Google Scholar 

  15. H. S. ITO, K. SHINOMYA and T. KAWAUCHI, J. Biomed. Mater. Res. 54 (2001) 445

    Article  Google Scholar 

  16. M. HUANG, J. Q. FENG, J. X. WANG, X. D. ZHANG, Y. B. LI and Y. G. YAN, J. Mater. Sci. Mater. Med. 14 (2003) 655

    Article  CAS  Google Scholar 

  17. M. KIKUCHI, S. ITIH, S. ICHINOSE, K. SHINOMIYA and J. TANAKA, Biomaterials 22 (2001) 1705

    Article  CAS  Google Scholar 

  18. T. CHANDY and C. P. SHARMA, Biomater. Artif. Cells Artif. Organs 18 (1990) 1

    CAS  Google Scholar 

  19. R. MURUGAN and S. RAMAKRISHNA, Biomaterials 25 (2004) 3829

    Article  CAS  Google Scholar 

  20. B. S. CHUNG , C. K. LEE , K. S. HONG, H. J. YOUN, H. S. RYU, S. S. CHUNG and K. W. PARK, Biomaterial 21 (2000) 1291

    Article  Google Scholar 

  21. A. LAHIJI and A. SOHRABI, J. Biomed. Mate.r Res. 49 (2000) 301

    Google Scholar 

  22. I. ADEKOGBE and A. GHANEM, Biomaterials 26 (2005) 7241

    Article  CAS  Google Scholar 

  23. R. MURUGAN and S. RAMAKRISHNA, Biomaterials 17 (2004) 3829

    Article  CAS  Google Scholar 

  24. K. H. WON, C. JONTHAN and K. H. EE, J .Biomed. Mater.Res. 72 (2005) 136

    Google Scholar 

  25. L. J. KONG, Y. GAO, W. L. CAO., Y. D. GONG, N. M. ZHAO and X. F. ZHANG, J. Biomed. Mater. Res, Part A 75 (2005) 275

    Article  CAS  Google Scholar 

  26. Y. F. MI, H. L. TAN and H. SUNG, Biomaterials 23 (2002) 181

    Article  CAS  Google Scholar 

  27. A. MORITZ, M. GRIMM, E. EYBL, M. GRABENWOGER, F. GRABENWOGER, P. BOCK and E. WOLNER, Eur.J.Cardiothorac. Surg. 5 (1991) 155

    Article  CAS  Google Scholar 

  28. F. J. SCHOEN, J. W. TSAO and R. J. LEVY, Am. J. Pathol. 123 (1986) 134

    CAS  Google Scholar 

  29. G. GOLOMB, F. J. SCHOEN, M. S. SMITH, J. LINDEN, M. NIXON and R. J. LEVY, Am. J. Pathol. 127 (1987) 122

    CAS  Google Scholar 

  30. E. EYBL, A. GRIESMACHER, M. GRIMM and E. WOLNOR, J. Biomed. Mater. Res. 23 (1989) 1355

    Article  CAS  Google Scholar 

  31. W. ARGÜELLES-MONAL and C. PENICHE-COVAS, Makromol. Chem. Rapid Commun. 9 (1998) 693

    Article  Google Scholar 

  32. H. FUKUDA and Y. KIKUCHI, Makromol. Chem. 180 (1979) 163

    Article  Google Scholar 

  33. L. ZHANG, Y. B. LI, X. J. WANG, X. L. PENG, Y. ZUO and J. M. HAN, High Tech.Lett. 10 (2004) 48

    CAS  Google Scholar 

  34. T. KOKUBO, H. KUSHITANI, S. SAKKA, T. KITSUGI and T. YAMAMURO, J Biomed. Mater. Res. 24 (1990) 723

    Google Scholar 

  35. L. WU, Y. B. LI, Y. ZUO, L. ZHANG, W. H. YANG and Y. H. MU, Mater. Sci. Forum 938 (2006) 510

    Google Scholar 

  36. M. TANAHASHI, T. KOKUBO, T. NAKAMURA, Y. KATSURA and M. NAGANO, Biomaterials 17 (1996) 47

    Article  CAS  Google Scholar 

  37. Q. Q. QIU, P. DUCHEYNE and P. S. AYYASWAMY, Biomaterials 52 (2000) 66

    CAS  Google Scholar 

  38. L. ZHANG, Y. B. LI, A. P. YANG, X. L. PENG, X. J. WANG and X. ZHANG, J. Mater. Sci. Mater. Med. 16 (2005) 213

    Article  CAS  Google Scholar 

  39. M. MARCOLONGO, P. DUCHEYNE, J. GARINO and E. SCHEPERS, J. Mater. Sci. Mater. Med. 39 (1998) 61

    Google Scholar 

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Acknowledgement

This study was funded by China-Netherlands programme strategic alliances (China 973 found: 2004CB720604).

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Authors and Affiliations

  1. Research Center for Nano-Biomaterials, Analytical & Testing Center, Sichuan University, Chengdu, 610064, China

    Jiang Liuyun, Li Yubao, Zhang Li & Liao Jianguo

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  1. Jiang Liuyun
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  2. Li Yubao
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  3. Zhang Li
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  4. Liao Jianguo
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Correspondence to Li Yubao.

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Liuyun, J., Yubao, L., Li, Z. et al. Preparation and properties of a novel bone repair composite: nano-hydroxyapatite/chitosan/carboxymethyl cellulose. J Mater Sci: Mater Med 19, 981–987 (2008). https://doi.org/10.1007/s10856-007-3208-1

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