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Alginate microsphere-collagen composite hydrogel for ocular drug delivery and implantation

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Abstract

A composite collagen hydrogel containing protein encapsulated alginate microspheres was developed for ocular applications. Bovine serum albumin (BSA) served as a drug model. The composite hydrogel retained optical clarity and mechanical robustness of control hydrogels without microspheres. A sustained release of BSA was achieved during an 11-day period in neutral phosphate buffer. The composite hydrogel supported human corneal epithelial cell growth and had adequate mechanical strength and excellent optical clarity for possible use as therapeutic lens for drug delivery and/or use as corneal substitute for transplantation into patients who have corneal diseases.

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Acknowledgements

The authors would like to thank Dona Grant for her help in cell culture, Neil Lagali for his assistance in confocal microscopic imaging.

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Authors and Affiliations

  1. Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada, K1H8M5

    Wenguang Liu & May Griffith

  2. University of Ottawa Eye Institute and Ottawa Health Research Institute, 501 Smyth Road, Ottawa, ON, Canada, K1H8L6

    Fengfu LI

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  1. Wenguang Liu
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  2. May Griffith
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  3. Fengfu LI
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Correspondence to Fengfu LI.

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Liu, W., Griffith, M. & LI, F. Alginate microsphere-collagen composite hydrogel for ocular drug delivery and implantation. J Mater Sci: Mater Med 19, 3365–3371 (2008). https://doi.org/10.1007/s10856-008-3486-2

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  • DOI: https://doi.org/10.1007/s10856-008-3486-2

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