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Drug sorption onto and release from soy protein fibers

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Abstract

Drug release in phosphate buffered saline (PBS pH 7.4) and artificial gastric juice (AGJ pH 1.2) and its relationship with kinetic and thermodynamic parameters of drug sorption onto soy protein (SP) fibers have been studied using Diclofenac, 5 Fluorouracil and Metformin as model drugs. Since SP is biodegradable, biocompatible, abundant and annually renewable, it has been widely used in medical applications. To understand drug release from SP fibers using sorption, kinetic and thermodynamic parameters have been investigated. Quantitative relationship between drug release and drug loading concentration, affinity, and activation energy for diffusion was established to predict initial bursts and later drug release. The study showed that Diclofenac had high initial bursts in PBS but more constant release in AGJ. It also has been found that drugs with lower diffusion coefficient and higher affinity (especially van der Waals force) on SP fiber are more suitable for sorption loading to achieve higher loading capacity and more constant releasing rate.

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Acknowledgement

We thank the Agricultural Research Division at the University of Nebraska-Lincoln, USDA Hatch Act and Multistate Project S1026, and the Nebraska Soybean Board for their financial support to complete this work. The financial sponsors do not endorse the views expressed in this article.

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Authors and Affiliations

  1. Department of Textiles, Clothing and Design, University of Nebraska-Lincoln, 234, HECO Building, Lincoln, NE, 68583-0802, USA

    Weijie Xu & Yiqi Yang

  2. Department of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE, 68583-0802, USA

    Yiqi Yang

  3. Nebraska Center for Materials and Nanoscience, University of Nebraska-Lincoln, Lincoln, NE, 68583-0802, USA

    Yiqi Yang

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  1. Weijie Xu
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Correspondence to Yiqi Yang.

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Xu, W., Yang, Y. Drug sorption onto and release from soy protein fibers. J Mater Sci: Mater Med 20, 2477–2486 (2009). https://doi.org/10.1007/s10856-009-3821-2

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  • DOI: https://doi.org/10.1007/s10856-009-3821-2

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