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Ester prodrug-loaded electrospun cellulose acetate fiber mats as transdermal drug delivery systems

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Abstract

Cellulose acetate (CA) fibers loaded with the ester prodrugs of naproxen, including methyl ester, ethyl ester and isopropyl ester, were prepared through electrospinning using acetone/N,N-dimethylacetamide(DMAc)/ethanol (4:1:1, v/v/v) as solvent. The chemical and morphological characterizations of the medicated fibers were investigated by means of SEM, DSC, XRD and FTIR, as well as the studies of the drug release properties. The results indicated that the morphology and diameter of the fibers were influenced by the concentration of spinning solution, applied voltage, electrospun solvent and the surfactants. The average diameters of the fibers ranged between 100 and 500 nm for three prodrugs. There was good compatibility between CA and three prodrugs in the blended fibers, respectively. In vitro release indicated that constant drug release from the fiber was observed over 6 days. The prodrugs were successfully encapsulated into the fibers, and this system was stable in terms of effectiveness in release.

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Acknowledgements

This work was financially supported by UK–CHINA Joint Laboratory for Therapeutic Textiles; Biomedical Textile Materials ‘‘111 Project’’ from Ministry of Education of P. R. China (No. B07024); China Postdoctoral Science Foundation (No. 20080440564); China Postdoctoral Science Foundation (Special Grade No. 200902195).

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Authors and Affiliations

  1. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Road, Shanghai, 201620, People’s Republic of China

    Xiao-mei Wu, Li-min Zhu & Deng-guang Yu

  2. Institute for Health Research and Policy, London Metropolitan University, 166-220 Holloway Road, London, N7 8DB, UK

    Christopher J. Branford-White & Nichoals P. Chatterton

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  1. Xiao-mei Wu
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  2. Christopher J. Branford-White
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  3. Li-min Zhu
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Correspondence to Li-min Zhu.

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Wu, Xm., Branford-White, C.J., Zhu, Lm. et al. Ester prodrug-loaded electrospun cellulose acetate fiber mats as transdermal drug delivery systems. J Mater Sci: Mater Med 21, 2403–2411 (2010). https://doi.org/10.1007/s10856-010-4100-y

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  • DOI: https://doi.org/10.1007/s10856-010-4100-y

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