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Influence of hyaluronic acid on bacterial and fungal species, including clinically relevant opportunistic pathogens

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Abstract

Hyaluronic acid (HA) has several clinical applications (aesthetic surgery, dermatology, orthopaedics and ophtalmology). Following recent evidence, suggesting antimicrobial and antiviral properties for HA, we investigated its effects on 15 ATCC strains, representative of clinically relevant bacterial and fungal species. The in vitro system employed allowed to assess optical density of broth cultures as a measure of microbial load in a time-dependent manner. The results showed that different microbial species and, sometimes, different strains belonging to the same species, are differently affected by HA. In particular, staphylococci, enterococci, Streptococcus mutans, two Escherichia coli strains, Pseudomonas aeruginosa, Candida glabrata and C. parapsilosis displayed a HA dose-dependent growth inhibition; no HA effects were detected in E. coli ATCC 13768 and C. albicans; S. sanguinis was favoured by the highest HA dose. Therefore, the influence of HA on bacteria and fungi warrants further studies aimed at better establishing its relevance in clinical applications.

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Acknowledgments

The Authors are grateful to IBSA (Institut Biochimique SA, CH-6903 Lugano), that founded part of the research activity and the salary of M.C.

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Authors and Affiliations

  1. Dipartimento di Scienze di Sanità Pubblica, Università di Modena e Reggio Emilia, Modena, Italy

    Andrea Ardizzoni, Rachele G. Neglia, Maria C. Baschieri, Claudio Cermelli, Manuela Caratozzolo & Elena Righi

  2. Dipartimento di Chirurgia Generale, Università di Modena e Reggio Emilia, Modena, Italy

    Beniamino Palmieri

  3. Dipartimento di Laboratori, Anatomia Patologica e Medicina Legale, Università di Modena e Reggio Emilia, Modena, Italy

    Elisabetta Blasi

  4. Istituti Biologici (2° piano), Via Campi 287, 41125, Modena, Italy

    Elisabetta Blasi

Authors
  1. Andrea Ardizzoni
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  2. Rachele G. Neglia
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  3. Maria C. Baschieri
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  4. Claudio Cermelli
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  5. Manuela Caratozzolo
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  6. Elena Righi
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  7. Beniamino Palmieri
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  8. Elisabetta Blasi
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Correspondence to Elisabetta Blasi.

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Ardizzoni, A., Neglia, R.G., Baschieri, M.C. et al. Influence of hyaluronic acid on bacterial and fungal species, including clinically relevant opportunistic pathogens. J Mater Sci: Mater Med 22, 2329 (2011). https://doi.org/10.1007/s10856-011-4408-2

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  • DOI: https://doi.org/10.1007/s10856-011-4408-2

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