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Electrospun fibrous scaffold of hydroxyapatite/poly (ε-caprolactone) for bone regeneration

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Abstract

Development of fibrous scaffold of hydroxyapatite/biopolymer nanocomposite offers great potential in the field of bone regeneration and tissue engineering. Hydroxyapatite (HA)/poly (ε-caprolactone) (PCL) fibrous scaffolds were successfully prepared by electrospinning dopes containing HA and PCL in this work. It was found that pre-treating HA with γ-glycioxypropyltrimethoxysilane (A-187) was effective in improving HA dispersion both in solutions and in a PCL matrix. Mechanical properties of the scaffolds were greatly enhanced by the filling of A187-HA. The bioactivity of PCL was remarkably improved by the addition of HA and A187-HA. Fibroblasts and osteoblasts were seeded on scaffolds to evaluate the effect of A-187 on biocompatibility of HA/PCL composites. Based on this study, good dispersion of HA in PCL matrix was granted by pretreatment of HA with A-187 and A187-HA/PCL fibrous scaffolds were obtained by electrospinning. These results demonstrated that the scaffolds may possess improved mechanical performance and good bioactivity due to A187-HA incorporation.

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Acknowledgments

This study was supported by the programme of Introducing Talents of Discipline to Universities (No. 111-2-04) in Shanghai, the Fund for Key Scientific and Technological Innovation in Zhejiang Province (2011R09039-07) and the scientific research programme of Department of Education in Zhejiang Province for Higher Education (Y201016694).

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Authors and Affiliations

  1. Affiliated Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, 325027, People’s Republic of China

    Lingli Li, Xiaona Liu, Li Luo & Kaihui Nan

  2. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai, 201620, People’s Republic of China

    Guang Li & Jianming Jiang

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  1. Lingli Li
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  2. Guang Li
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Correspondence to Lingli Li.

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Li, L., Li, G., Jiang, J. et al. Electrospun fibrous scaffold of hydroxyapatite/poly (ε-caprolactone) for bone regeneration. J Mater Sci: Mater Med 23, 547–554 (2012). https://doi.org/10.1007/s10856-011-4495-0

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  • DOI: https://doi.org/10.1007/s10856-011-4495-0

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