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Mesoporous bioactive glass as a drug delivery system: fabrication, bactericidal properties and biocompatibility

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Abstract

Implant-associated infection remains a difficult medical problem in orthopaedic surgery. Here, we report on the fabrication of gentamicin-loaded mesoporous bioactive glass (Gent-MBG) for use as a controlled antibiotic delivery system to achieve the sustained release of antibiotics in the local sites of bone defects. The high surface area and mesoporous structure of MBG enable higher drug loading efficiency (79–83 %) than non-mesoporous biological glass (NBG) (18–19 %). Gent-MBG exhibits sustained drug release for more than 6 days, and this controlled release of gentamicin significantly inhibits bacterial adhesion and prevents biofilm formation by S. aureus (ATCC25923) and S. epidermidis (ATCC35984). Biocompatibility tests with human bone marrow stromal cells (hBMSCs) indicate that MBG has better biocompatibility than NBG. Therefore, Gent-MBG can be used as a controlled drug delivery system to prevent and/or treat orthopedic peri-implant infections.

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Acknowledgments

This research was supported by Fund for Key Disciplines of Shanghai Municipal Education Commission (J50206), Natural Science Foundation of China (Nos. 30973038 and 51002095), Science and Technology Commission of Shanghai Municipality (No. 12JC1405600), the Innovation Foundation of Shanghai Education Committee (No. 11YZ86), and the Special Research Fund for Cultivating Outstanding Young Teachers in Shanghai Universities (No. ssd10008). The project was also funded by the State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Dong Hua University.

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Authors and Affiliations

  1. Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, People’s Republic of China

    Yang Li, Teng Long, Ting–Ting Tang, Ke-Rong Dai, Bo Tian & Zhen-An Zhu

  2. Department of Chemistry, Shanghai Normal University, Shanghai, 200234, People’s Republic of China

    Yi-Zhuo Liu, Xi-Bin Yu & Ya-Ping Guo

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  1. Yang Li
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Correspondence to Ya-Ping Guo or Zhen-An Zhu.

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Yang Li and Yi-Zhuo Liu equally contributed to this work.

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Li, Y., Liu, YZ., Long, T. et al. Mesoporous bioactive glass as a drug delivery system: fabrication, bactericidal properties and biocompatibility. J Mater Sci: Mater Med 24, 1951–1961 (2013). https://doi.org/10.1007/s10856-013-4960-z

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  • DOI: https://doi.org/10.1007/s10856-013-4960-z

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