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Recyclable heparin and chitosan conjugated magnetic nanocomposites for selective removal of low-density lipoprotein from plasma

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Abstract

A new fabrication protocol is described to obtain heparin and chitosan conjugated magnetic nanocomposite as a blood purification material for removal of low-density lipoprotein (LDL) from blood plasma. The adsorbent could be easily separated with an external magnet for recyclable use since it had a magnetic core. The LDL level of plasma decreased by 67.3 % after hemoperfusion for 2 h. Moreover, the adsorbent could be recycled simply washing with NaCl solution. After eight cycles, the removal efficiency of the adsorbent was still above 50 %. The recyclable magnetic adsorbent had good blood compatibility due to the conjugation of heparin to the chitosan-coated magnetic nanocomposites. The fabricated magnetic adsorbent could be applied for LDL apheresis without side effects.

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Acknowledgments

This work was financially supported by Natural Science Foundation of Chongqing Municipal Government (CSTC, 2011JJJQ10004), Natural Science Foundation of China (51173216, 11032012 and 31170923), Chongqing University Innovative Talent Training Project of the Third Stage of “211 Project” (#S-09104) and Fundamental Research Funds for the Central Universities (Project No. CDJXS10 23 22 11).

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Authors and Affiliations

  1. Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, People’s Republic of China

    Jinghua Li, Yanhua Hou, Xiuyong Chen, Xingwei Ding, Yun Liu, Xinkun Shen & Kaiyong Cai

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  1. Jinghua Li
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  2. Yanhua Hou
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  3. Xiuyong Chen
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  4. Xingwei Ding
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Correspondence to Kaiyong Cai.

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Li, J., Hou, Y., Chen, X. et al. Recyclable heparin and chitosan conjugated magnetic nanocomposites for selective removal of low-density lipoprotein from plasma. J Mater Sci: Mater Med 25, 1055–1064 (2014). https://doi.org/10.1007/s10856-013-5134-8

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  • DOI: https://doi.org/10.1007/s10856-013-5134-8

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