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Synthesis and characterization of cerium- and gallium-containing borate bioactive glass scaffolds for bone tissue engineering

  • Biomaterials Synthesis and Characterization
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Abstract

Bioactive glasses are widely used in biomedical applications due to their ability to bond to bone and even to soft tissues. In this study, borate based (13-93B3) bioactive glass powders containing up to 5 wt% Ce2O3 and Ga2O3 were prepared by the melt quench technique. Cerium (Ce+3) and gallium (Ga+3) were chosen because of their low toxicity associated with bacteriostatic properties. Bioactive glass scaffolds were fabricated using the polymer foam replication method. In vitro degradation and bioactivity of the scaffolds were evaluated in SBF under static conditions. Results revealed that the cerium- and gallium-containing borate glasses have much lower degradation rates compared to the bare borate glass 13-93B3. In spite of the increased chemical durability, substituted glasses exhibited a good in vitro bioactive response except when the Ce2O3 content was 5 wt%. Taking into account the high in vitro hydroxyapatite forming ability, borate glass scaffolds containing Ce+3 and Ga+3 therapeutic ions are promising candidates for bone tissue engineering applications.

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Acknowledgments

Support of Prof. Mohamed N.Rahaman (Missouri S&T, Rolla, USA) is greatly appreciated. The author would like to thank Xin Liu for technical assistance and Mehmet Yıldırım for performing microhardness measurements. The financial support for this research was provided by the Scientific and Technical Research Council of Turkey in the form of a TUBITAK 2219 fellowship and 1001 grant program for scientific and technological research projects; Grant No: 111M766.

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  1. Department of Materials Science and Engineering, and Center for Bone and Tissue Repair and Regeneration, Missouri University of Science and Technology, Rolla, MO, USA

    Aylin M. Deliormanlı

  2. Department of Materials Engineering, Celal Bayar University, Manisa, Turkey

    Aylin M. Deliormanlı

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Correspondence to Aylin M. Deliormanlı.

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Deliormanlı, A.M. Synthesis and characterization of cerium- and gallium-containing borate bioactive glass scaffolds for bone tissue engineering. J Mater Sci: Mater Med 26, 67 (2015). https://doi.org/10.1007/s10856-014-5368-0

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