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Amino Acid Coated Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications Through a Novel Efficient Preparation Method

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Abstract

An efficient and applicable method to synthesize the amino acid coated magnetite nanoparticles (MNPs) was developed. A quality control of the amino acid coated MNPs were performed by various techniques of X-ray diffraction, FT-IR, FE-SEM, TEM, DLS, VSM and DSC-TGA techniques. Structural analyses by XRD and IR confirmed that the electro-synthesized samples have composition of pure magnetite (Fe3O4) phase with crystal size of about 8 nm. Morphological characterization by FE-SEM and TEM showed that all the prepared samples have uniform spherical particles with size about 10 nm. The amine coat on the surface of MNPs was confirmed by FT-IR, DSC-TGA and DLS analyses. The superparamagnetic properties of the prepared NPs were verified by VSM data, where the lysine coated Fe3O4 NPs exhibited suitable magnetization value (Ms = 55.9 emu g−1), negligible coercivity (Ce = 0.9 Oe) and magnetic remanence (Mr = 0.55 emu g−1) values. The results confirmed that the prepared amino acid coated MNPs have proper size, dispersion and magnetic properties for biomedical applications.

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Authors and Affiliations

  1. Shefa Neuroscience Research Center, Khatam ol Anbia Hospital, Tehran, Iran

    Isa Karimzadeh, Taher Doroudi & Peir Hossein Kolivand

  2. Department of Physics, Faculty of Science, Islamic Azad University, Tehran, Iran

    Isa Karimzadeh

  3. NFCRS, Nuclear Science and Technology Research Institute (NSTRI), P.O. Box 14395-834, Tehran, Iran

    Mustafa Aghazadeh

  4. Center of Excellence in Electrochemistry, Faculty of Chemistry, University of Tehran, Tehran, Iran

    Mohammad Reza Ganjali & Davoud Gharailou

Authors
  1. Isa Karimzadeh
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  2. Mustafa Aghazadeh
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  3. Taher Doroudi
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  4. Mohammad Reza Ganjali
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  5. Peir Hossein Kolivand
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  6. Davoud Gharailou
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Correspondence to Mustafa Aghazadeh.

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Karimzadeh, I., Aghazadeh, M., Doroudi, T. et al. Amino Acid Coated Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications Through a Novel Efficient Preparation Method. J Clust Sci 28, 1259–1271 (2017). https://doi.org/10.1007/s10876-016-1139-z

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  • DOI: https://doi.org/10.1007/s10876-016-1139-z

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