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Novel Heptamethine Cyanine Dyes with Large Stokes’ Shift for Biological Applications in the Near Infrared

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Abstract

A series of novel functionalized, water-soluble, pH-unsensitive, highly photostable heptamethine cyanine dyes (HCDs) has been synthesized. The aim of the synthesis was to obtain novel effective probes for fluorescence detection in the near infrared. Synthesis and characterization of a special HCD with large Stokes’ shift (>100 nm), bioconjugation to IgG and effect of pH upon the new structure are presented.

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Acknowledgements

This work was part of Lagrange Project (CRT and ISI Foundation). The authors thank Compagnia di San Paolo and Fondazione CRT, Torino Italy for continuous equipment supply.

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Authors and Affiliations

  1. Dipartimento di Chimica IFM, Università di Torino, Via P. Giuria 7, 10125, Torino, Italy

    Chiara A. Bertolino, Giuseppe Caputo & Salvatore Coluccia

  2. ISI Foundation, Lagrange Project, Viale Settimio Severo 65, 10133, Torino, Italy

    Chiara A. Bertolino

  3. NIS Centre of Excellence, Università di Torino, Via P. Giuria 7, 10125, Torino, Italy

    Chiara A. Bertolino, Giuseppe Caputo, Claudia Barolo, Guido Viscardi & Salvatore Coluccia

  4. Dipartimento di Chimica Generale ed Organica Applicata, Università di Torino, Corso Massimo d’Azeglio 48, 10125, Torino, Italy

    Claudia Barolo & Guido Viscardi

Authors
  1. Chiara A. Bertolino
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  2. Giuseppe Caputo
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  3. Claudia Barolo
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  4. Guido Viscardi
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  5. Salvatore Coluccia
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Correspondence to Chiara A. Bertolino.

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Bertolino, C.A., Caputo, G., Barolo, C. et al. Novel Heptamethine Cyanine Dyes with Large Stokes’ Shift for Biological Applications in the Near Infrared. J Fluoresc 16, 221–225 (2006). https://doi.org/10.1007/s10895-006-0094-8

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  • DOI: https://doi.org/10.1007/s10895-006-0094-8

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