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A Mixture of Experts Network Structure for Breast Cancer Diagnosis

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Abstract

Mixture of experts (ME) is a modular neural network architecture for supervised learning. This paper illustrates the use of ME network structure to guide diagnosing of breast cancer. Expectation-maximization (EM) algorithm was used for training the ME so that the learning process is decoupled in a manner that fits well with the modular structure. Diagnosis tasks are among the most interesting activities in which to implement intelligent systems. Specifically, diagnosis is an attempt to accurately forecast the outcome of a specific situation, using as input information obtained from a concrete set of variables that potentially describe the situation. The ME network structure was implemented for breast cancer diagnosis using the attributes of each record in the Wisconsin breast cancer database. To improve diagnostic accuracy, the outputs of expert networks were combined by a gating network simultaneously trained in order to stochastically select the expert that is performing the best at solving the problem. For the Wisconsin breast cancer diagnosis problem, the obtained total classification accuracy by the ME network structure was 98.85%. The ME network structure achieved accuracy rates which were higher than that of the stand-alone neural network models.

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References

  • Jacobs, R. A., Jordan, M. I., Nowlan, S. J., and Hinton, G. E., Adaptive mixtures of local experts. Neural Comput. 3(1):79–87, 1991.

    Google Scholar 

  • Chen, K., Xu, L., and Chi, H., Improved learning algorithms for mixture of experts in multiclass classification. Neural Netw. 12(9):1229–1252, 1999.

    Article  PubMed  Google Scholar 

  • Hong, X., and Harris, C. J., A mixture of experts network structure construction algorithm for modelling and control. Appl. Intell. 16(1):59–69, 2002.

    Article  Google Scholar 

  • Jordan, M. I., and Jacobs, R. A., Hierarchical mixture of experts and the EM algorithm. Neural Comput. 6(2):181–214, 1994.

    Google Scholar 

  • Mangiameli, P., and West, D., An improved neural classification network for the two-group problem. Comput. Oper. Res. 26(5):443–460, 1999.

    Article  Google Scholar 

  • Hu, Y. H., Palreddy, S., and Tompkins, W. J., A patient-adaptable ECG beat classifier using a mixture of experts approach. IEEE Trans. Biomed. Eng. 44(9):891–900, 1997.

    Article  PubMed  Google Scholar 

  • Güler, İ., and Übeyli, E. D., A mixture of experts network structure for modelling Doppler ultrasound blood flow signals. Comput. Biol. Med. 35(7):565–582, 2005.

    Article  Google Scholar 

  • Baxt, W. G., Use of an artificial neural network for data analysis in clinical decision making: The diagnosis of acute coronary occlusion. Neural Comput. 2:480–489, 1990.

    Google Scholar 

  • Miller, A. S., Blott, B. H., and Hames, T. K., Review of neural network applications in medical imaging and signal processing. Med. Biol. Eng. Comput. 30:449–464, 1992.

    PubMed  Google Scholar 

  • West, D., and West, V., Model selection for a medical diagnostic decision support system: A breast cancer detection case. Artif. Intell. Med. 20(3):183–204, 2000.

    Article  PubMed  Google Scholar 

  • Setiono, R., Extracting rules from pruned neural networks for breast cancer diagnosis. Artif. Intell. Med. 8(1):37–51, 1996.

    Article  PubMed  Google Scholar 

  • Setiono, R., Generating concise and accurate classification rules for breast cancer diagnosis. Artif. Intell. Med. 18(3):205–219, 2000.

    Article  PubMed  Google Scholar 

  • Wolberg, W. H., and Mangasarian, O. L., Multisurface method of pattern separation for medical diagnosis applied to breast cytology. In Proceedings of the National Academy of Sciences, Vol. 87, Washington, pp. 9193–9196, December 1990.

  • Jerez-Aragones, J. M., Gomez-Ruiz, J. A., Ramos-Jimenez, G., Munoz-Perez, J., and Alba-Conejo, E., A combined neural network and decision trees model for prognosis of breast cancer relapse. Artif. Intell. Med. 27(1):45–63, 2003.

    PubMed  Google Scholar 

  • Basheer, I. A., and Hajmeer, M., Artificial neural networks: Fundamentals, computing, design, and application. J. Microbiol. Methods 43(1):3–31, 2000.

    Article  PubMed  Google Scholar 

  • Chaudhuri, B. B., and Bhattacharya, U., Efficient training and improved performance of multilayer perceptron in pattern classification. Neurocomputing 34:11–27, 2000.

    Article  Google Scholar 

  • Haykin, S., Neural Networks: A Comprehensive Foundation, MacMillan, New York, 1994.

    Google Scholar 

  • Zweig, M. H., and Campbell, G., Receiver-operating characteristic (ROC) plots: A fundamental evaluation tool in clinical medicine. Clin. Chem. 39(4):561–577, 1993.

    PubMed  Google Scholar 

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Correspondence to Elif Derya Übeyli.

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Übeyli, E.D. A Mixture of Experts Network Structure for Breast Cancer Diagnosis. J Med Syst 29, 569–579 (2005). https://doi.org/10.1007/s10916-005-6112-6

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