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Biodegradable Microspheres for Controlled Release of an Antibiotic Ciprofloxacin

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Abstract

Ciprofloxacin (CF) loaded biodegradable microspheres of Poly(lactide-co-caprolactone)-PF127 (a poloxamer block copolymer of Ethylene Oxide/Propylene Oxide) were prepared by using solvent evaporation technique. The microspheres were characterized by differential scanning calorimetry (DSC) and X-ray diffractometry (X-RD) technique to confirm the polymorphism of ciproflaxacin (CF) drug. The X-RD and DSC techniques indicated molecular level dispersion of CF in the microspheres. Scanning electron micrographic images (SEM) of the microspheres indicated smooth surfaces of the spherical microspheres. Cumulative release characteristics of the matrices for CF, the antibiotic drug, were investigated in pH 7.4 media. It was possible to release CF in controlled manner up to 72 h. The developed ciprofloxacin loaded Poly(lactide-co-caprolactone)-PF127 microspheres were evaluated for preliminary antibacterial applications.

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Acknowledgments

The authors (KMR & SR) thanks the University Grants Commission (UGC-SAP), Government of India, New Delhi for the partial financial support.

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Authors and Affiliations

  1. Synthetic Polymer Laboratory, Department of Polymer Science and Technology, Sri Krishnadevaraya University, Anantapur, A.P., 515055, India

    S. Ravindra, K. Varaprasad, N. Narayana Reddy, K. Vimala & K. Mohana Raju

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  1. S. Ravindra
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  2. K. Varaprasad
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  3. N. Narayana Reddy
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  4. K. Vimala
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  5. K. Mohana Raju
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Correspondence to K. Mohana Raju.

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Ravindra, S., Varaprasad, K., Narayana Reddy, N. et al. Biodegradable Microspheres for Controlled Release of an Antibiotic Ciprofloxacin. J Polym Environ 19, 413–418 (2011). https://doi.org/10.1007/s10924-011-0290-8

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  • DOI: https://doi.org/10.1007/s10924-011-0290-8

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