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Journal of Polymer Research
Erschienen in: Journal of Polymer Research 4/2010

01.07.2010 | Original Paper

A novel biodegradable amphiphilic diblock copolymers based on poly(lactic acid) and hyaluronic acid as biomaterials for drug delivery

verfasst von: Chia Chang Liu, Ken Yuan Chang, Yng Jiin Wang

Erschienen in: Journal of Polymer Research | Ausgabe 4/2010

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Abstract

An amphiphilic poly((lactic acid)-b-hyaluronic acid) diblock copolymer, poly(LA-b-HA), was synthesized from short-chain hyaluronic acid and poly(lactic acid). The synthesis was conducted by coupling the N, N′- dicyclohexylcarbodiimide activated poly(lactic acid) to a short-chain hyaluronic acid which was pre-aminated with 1, 2-ethylenediamine at the reducing end followed by NaCNBH3 reduction. The poly (LA-b-HA) copolymers synthesized were verified by the spectral analyses of FTIR and 1H NMR. The poly(LA-b-HA) molecules can self-assemble into micelles in aqueous solution. The average diameters of polymeric micelles were estimated to be 116 ± 17 and 98 ± 11 nm for the polymeric micelles derived from the poly(lactic acid)s of MW 3,200 and MW 16,900, respectively. The poly(LA-b-HA) copolymeric material is non-cytotoxic and can be used as micellar drug carriers. The drug encapsulation capabilities of these poly(LA-b-HA) micelles were demonstrated by using ellagic acid and lidocaine chloride as model compounds. These new biodegradable micelles have a great potential to be used as drug delivery carrier for biomedical applications.
Nächster Artikel Preparation and swelling kinetics of pH-sensitive photocrosslinked hydrogel based on carboxymethyl chitosan

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Metadaten
Titel
A novel biodegradable amphiphilic diblock copolymers based on poly(lactic acid) and hyaluronic acid as biomaterials for drug delivery
verfasst von
Chia Chang Liu
Ken Yuan Chang
Yng Jiin Wang
Publikationsdatum
01.07.2010
Verlag
Springer Netherlands
Erschienen in
Journal of Polymer Research / Ausgabe 4/2010
Print ISSN: 1022-9760
Elektronische ISSN: 1572-8935
DOI
https://doi.org/10.1007/s10965-009-9332-5

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