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Isolation of generator-produced 223Ra in 0.9-% NaCl solutions containing EDTA for direct radiotherapeutic studies

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Abstract

A novel approach to the preparation of the α-emitting radionuclide 223Ra was proposed to be applied for direct treatment of bone metastases and targeted alpha-radioimmunotherapy. The tandem generator system based on ion exchange columns was developed for isolation of 223Ra in the form of 223Ra-EDTA complexes in 0.9 % NaCl solutions at pH = 7.4–8.0. Advantages of the method for routine laboratory work and clinical implementations are discussed.

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Acknowledgments

The authors are grateful to Head of the Laboratory of Radiochemistry GEOKHI RAS Dr. Yury M. Kulyako for helpful discussions and support; Dr. Dmitry A. Malikov and Dr. Trofim I. Trofimov for their kind help with the alpha-spectrometric measurements.

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Authors and Affiliations

  1. Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, 19 Kosygin Street, 119991, Moscow, Russia

    Olga Mokhodoeva, Lidiya Guseva & Nikolay Dogadkin

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  1. Olga Mokhodoeva
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  2. Lidiya Guseva
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  3. Nikolay Dogadkin
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Correspondence to Olga Mokhodoeva.

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Mokhodoeva, O., Guseva, L. & Dogadkin, N. Isolation of generator-produced 223Ra in 0.9-% NaCl solutions containing EDTA for direct radiotherapeutic studies. J Radioanal Nucl Chem 304, 449–453 (2015). https://doi.org/10.1007/s10967-014-3777-7

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  • DOI: https://doi.org/10.1007/s10967-014-3777-7

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