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Compatibility studies between captopril and pharmaceutical excipients used in tablets formulations

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Abstract

Captopril (CAP) was the first commercially available angiotensine-converting enzyme (ACE) inhibitor. In the anti-hypertensive therapy is considered the selected drug has to be therapeutically effective together with reduced toxicity. CAP is an antihypertensive drug currently being administered in tablet form. In order to investigate the possible interactions between CAP and excipients in tablets formulations, differential scanning calorimetry (DSC) and thermogravimetric (TG) analysis completed by X-ray powder diffraction (XRPD) and Fourier transform infrared spectroscopy (FTIR) were used for compatibility studies. A possible drug-excipient interaction was observed with magnesium stearate by DSC technique.

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Authors and Affiliations

  1. Department of Science Pharmacy, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil

    H. K. Stulzer, P. O. Rodrigues, T. M. Cardoso & M. A. S. Silva

  2. Department of Elementar Chemistry, Chemistry Institute, Universidade de São Paulo, São Paulo, SP, Brazil

    J. S. R. Matos

Authors
  1. H. K. Stulzer
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  2. P. O. Rodrigues
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  3. T. M. Cardoso
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  4. J. S. R. Matos
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  5. M. A. S. Silva
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Correspondence to H. K. Stulzer.

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Stulzer, H.K., Rodrigues, P.O., Cardoso, T.M. et al. Compatibility studies between captopril and pharmaceutical excipients used in tablets formulations. J Therm Anal Calorim 91, 323–328 (2008). https://doi.org/10.1007/s10973-006-7935-1

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  • DOI: https://doi.org/10.1007/s10973-006-7935-1

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