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Characterization of palygorskite clay from Piauí, Brazil and its potential use as excipient for solid dosage forms containing anti-tuberculosis drugs

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Abstract

Clays play an important role in health products as it has been used as excipients for solid dosage forms and as active ingredients. Usually, excipients are pharmacologically inert, but they can interact with drugs in the solid dosage form and affect their bioavailability. Thus, the aim of this work was to determinate the physicochemical properties of palygorskite clay from Piauí, Brazil, and to investigate the potential use of this mineral as excipient for solid dosage forms containing rifampicin and isoniazid, which are drugs currently used to treat tuberculosis. Palygorskite was analyzed by X-ray fluorescence, X-ray diffraction, transmission electron microscopy, and particle size analyzer. According to the results, the main component found was SiO2, and its mineral composition contains palygorskite, dolomite, and quartz. The particles appear as fibers with bundle-like aspect that cluster together to form aggregates. The results from thermal analysis indicate that there is no interaction between both rifampicin and isoniazid with palygorskite. Moreover, the presence of palygorskite did not interfere on the dissolution of these drugs, which suggests that this material can be potentially used as an excipient for these drugs.

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Acknowledgements

The authors wish to thank NUPLAM/UFRN for the supply the samples and FAPERN and CNPq for financial support for this project.

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Authors and Affiliations

  1. Laboratório de Desenvolvimento de Medicamentos, Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, 59010-180, Brazil

    Daiane dos Santos Soares

  2. Laboratório de Desenvolvimento de Medicamento, Curso de Farmácia, Universidade Federal do Rio Grande Do Norte (UFRN), Natal, RN, 59010-180, Brazil

    Caio Santana Fernandes

  3. Programa de Pós-Graduação em Ciência e Engenharia de Materiais, Universidade Federal Do Rio Grande do Norte (UFRN), Natal, RN, 59072-970, Brazil

    Antônio Carlos S. da Costa

  4. Departamento de Física, Universidade Federal Do Rio Grande do Norte (UFRN), Natal, RN, 59072-970, Brazil

    Wilson Acchar

  5. Laboratório de Desenvolvimento de Medicamentos, Departamento de Farmácia, Universidade Federal do Rio Grande Do Norte (UFRN), R. Brigadeiro Cordeiro de Farias, s/n, Petrópolis, Natal, RN, 59010-180, Brazil

    Fernanda Nervo Raffin & Túlio F. A. de Lima e Moura

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  1. Daiane dos Santos Soares
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  2. Caio Santana Fernandes
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  3. Antônio Carlos S. da Costa
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  4. Fernanda Nervo Raffin
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  5. Wilson Acchar
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  6. Túlio F. A. de Lima e Moura
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Correspondence to Túlio F. A. de Lima e Moura.

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dos Santos Soares, D., Fernandes, C.S., da Costa, A.C.S. et al. Characterization of palygorskite clay from Piauí, Brazil and its potential use as excipient for solid dosage forms containing anti-tuberculosis drugs. J Therm Anal Calorim 113, 551–558 (2013). https://doi.org/10.1007/s10973-013-3291-0

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  • DOI: https://doi.org/10.1007/s10973-013-3291-0

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