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Physico-chemical characterisation of a new polymorph of caffeine

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Abstract

Caffeine is a widely used drug substance. Two polymorphic forms and one hydrate of caffeine are known. Thanks to scanning transitiometry, the curves pressure versus temperature, P = f(T), of the caffeine were plotted. A (temperature, pressure) unary phase diagram was deduced. It confirms the existence of a new polymorph of caffeine at low pressure synthesized by sublimation. Its identification and its physico-chemical properties were determined using a variety of experimental methods: X-ray powder diffraction, differential scanning calorimeter, thermogravimetric analysis, thermally stimulated current and electrochemical impedance.

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Authors and Affiliations

  1. Matériaux et Santé, EA 401 Faculté de Pharmacie, Université Paris Sud, 5 rue J. B. Clément, 92296, Châtenay-Malabry, France

    Emma Dichi, Bernard Legendre & Mehrez Sghaier

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  1. Emma Dichi
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  2. Bernard Legendre
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  3. Mehrez Sghaier
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Correspondence to Emma Dichi.

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Dichi, E., Legendre, B. & Sghaier, M. Physico-chemical characterisation of a new polymorph of caffeine. J Therm Anal Calorim 115, 1551–1561 (2014). https://doi.org/10.1007/s10973-013-3429-0

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