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Thermal behavior of sodium alendronate

A kinetic study under non-isothermal conditions

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Abstract

The thermal behavior of sodium alendronate trihydrate under non-isothermal behavior was studied by thermogravimetry and evolved gas analysis. Three steps of thermodegradation were observed: water loss, with a DTG max at 130 °C, ammonia loss (DTG max at 260 °C) and a complex degradation and pyrolysis to sodium pyrophosphate. A deamination mechanism (second step) was suggested and supported by the evolved gas analysis and the determined thermal effect. An elaborated kinetic study using four data processing methods (FR, FWO, KAS and NPK) confirms that the dehydration is a multistep process.

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Authors and Affiliations

  1. Research Center for Thermal Analysis in Environmental Problems, West University of Timisoara, 16 Pestalozzi St., 300115, Timisoara, Romania

    Paul Albu, Gabriela Vlase & Titus Vlase

  2. Department of Pharmacy, Faculty of Medicine, Pharmacy and Dental Medicine “Vasile Goldis”, West University of Arad, 86 L. Rebreanu St., 310414, Arad, Romania

    Paul Albu

  3. University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Square 2, 300041, Timisoara, Romania

    Sorin Cristian Doca & Andrei Anghel

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  1. Paul Albu
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  2. Sorin Cristian Doca
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  4. Gabriela Vlase
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Correspondence to Gabriela Vlase.

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Albu, P., Doca, S.C., Anghel, A. et al. Thermal behavior of sodium alendronate. J Therm Anal Calorim 127, 571–576 (2017). https://doi.org/10.1007/s10973-016-5745-7

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  • DOI: https://doi.org/10.1007/s10973-016-5745-7

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