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Valorization of Lipopeptides Biosurfactants as Anticancer Agents

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International Journal of Peptide Research and Therapeutics Aims and scope Submit manuscript

Abstract

Biosurfactants are natural compounds produced biologically by certain bacterial strains. They are promising alternatives in several applications due to their biocompatibility, biodegradability and reduced toxicity. Systemic toxicity problems and drug resistance in tumor chemotherapy are urging the continued discovery of new antitumor agents. Biosurfactants have significant effect in inhibiting multiple tumor types. Specifically, surfactin, iturin, and fengycin lipopeptide biosurfactant were previously produced from several bacterial species belonging to Bacillus genus. Only few previous studies investigated their cytotoxicity against some tumor types such as breast, colon, leukemia, hepatoma and others. Due to the probability of being potential antitumor treatments, biosurfactants nanoparticles could be clinically recommended. This review discussed the properties of biologically-produced biosurfactants and their antitumor activities against distinctive cancer models. Additionally, it underlines their potential mechanisms and sheds light on the discovery of new active bioproducts.

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Abbreviations

ERK:

Extracellular sign controlled kinase

ERS:

Endoplasmic reticulum stress

DOX:

Doxorubicin

IC50 :

Half inhibition concentration

Bcl-xL:

B-cell lymphoma-extra large

MDR:

Multidrug Resistant

HMEC:

Human mammary epithelial cells

TPA:

Tetradecanoylphorbol-13-acetic acid

ROS/JNK:

Reactive oxygen species/c-Jun N-terminal kinase

Akt:

Protein Kinase B pathway

MMP-9:

Matrix metallopeptidase-9

MPTP:

Mitochondrial penetrability change pore

ROS:

Reactive oxygen species

BH3:

BCL-2 homology

CLPs:

Crude cyclic lipopeptides

Cyto-C:

Cytochrome-C

Bcl-2:

B-cell lymphoma 2

PS:

Phosphatidylserine

MOMP:

Mitochondrial outer membrane permeabilization

Apaf-1:

Apoptotic protease activating factor-1

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  1. Department of Botany and Microbiology, Faculty of Science, Alexandria University, Alexandria, Egypt

    Marian Rofeal & Fady Abd El-Malek

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  1. Marian Rofeal
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Rofeal, M., El-Malek, F.A. Valorization of Lipopeptides Biosurfactants as Anticancer Agents. Int J Pept Res Ther 27, 447–455 (2021). https://doi.org/10.1007/s10989-020-10105-8

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