Abstract
Tubulin-binding agents play a pivotal role in current cancer therapy and there are many efforts in pre-clinical and clinical development of known and novel cytotoxic agents ongoing. In this article a known class, epothilones, as well as a novel class, tubulysins, are presented.
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Abbreviations
- GI50:
-
concentration of 50% growth inhibition
- HUVEC:
-
human umbilical vein endothelial cell
- MCR:
-
multicomponent reaction
- MDR:
-
multiple drug resistance
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Dömling, A., Richter, W. Myxobacterial epothilones and tubulysins as promising anticancer agents. Mol Divers 9, 141–147 (2005). https://doi.org/10.1007/s11030-005-1542-0
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DOI: https://doi.org/10.1007/s11030-005-1542-0